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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2007 Volume 18 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2007 Volume 18 Issue 5

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Article

Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin

  • Authors:
    • Tatsushi Yoshida
    • Takumi Shiraishi
    • Mano Horinaka
    • Miki Wakada
    • Toshiyuki Sakai
  • View Affiliations / Copyright

    Affiliations: Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  • Pages: 1239-1242
    |
    Published online on: November 1, 2007
       https://doi.org/10.3892/or.18.5.1239
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Abstract

Death receptor 4 (DR4) is a receptor of the antitumor death ligand, TNF-related apoptosis-inducing ligand (TRAIL), and is considered a promising molecular target for cancer therapy. Here, we show a novel regulation of DR4 protein. Tunicamycin treatment, which is an inducer of endoplasmic reticulum (ER)-stress, generated a lower molecular-weight pattern of DR4, but not DR5 protein in prostate cancer DU145 and PC3 cells. Thus, we termed the small form of DR4 protein, DR4-Small (DR4-S) and the large form, DR4-Large (DR4-L). Using DR4 siRNA, we confirmed that DR4-S also stands for DR4 protein. Other ER-stress inducers, brefeldin A and thapsigargin did not generate DR4-S. On the other hand, these ER-stress inducers increased DR5 protein. Tunicamycin induces ER-stress following the inhibition of N-linked glycosylation. Thus, we examined DR4 protein in cell lysates treated with glycosydase. Glycosydase treatments generated DR4-S protein, similar to tunicamycin. These results indicate that tunicamycin regulates DR4 protein size via inhibition of glycosylation.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshida T, Shiraishi T, Horinaka M, Wakada M and Sakai T: Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin. Oncol Rep 18: 1239-1242, 2007.
APA
Yoshida, T., Shiraishi, T., Horinaka, M., Wakada, M., & Sakai, T. (2007). Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin. Oncology Reports, 18, 1239-1242. https://doi.org/10.3892/or.18.5.1239
MLA
Yoshida, T., Shiraishi, T., Horinaka, M., Wakada, M., Sakai, T."Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin". Oncology Reports 18.5 (2007): 1239-1242.
Chicago
Yoshida, T., Shiraishi, T., Horinaka, M., Wakada, M., Sakai, T."Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin". Oncology Reports 18, no. 5 (2007): 1239-1242. https://doi.org/10.3892/or.18.5.1239
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida T, Shiraishi T, Horinaka M, Wakada M and Sakai T: Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin. Oncol Rep 18: 1239-1242, 2007.
APA
Yoshida, T., Shiraishi, T., Horinaka, M., Wakada, M., & Sakai, T. (2007). Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin. Oncology Reports, 18, 1239-1242. https://doi.org/10.3892/or.18.5.1239
MLA
Yoshida, T., Shiraishi, T., Horinaka, M., Wakada, M., Sakai, T."Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin". Oncology Reports 18.5 (2007): 1239-1242.
Chicago
Yoshida, T., Shiraishi, T., Horinaka, M., Wakada, M., Sakai, T."Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin". Oncology Reports 18, no. 5 (2007): 1239-1242. https://doi.org/10.3892/or.18.5.1239
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