Induction of apoptosis increases expression of non-canonical WNT genes in myeloid leukemia cell lines

  • Authors:
    • Hakki Ogun Sercan
    • Melek Pehlivan
    • Ozlenen Simsek
    • Halil Ates
    • Zeynep Sercan
  • View Affiliations

  • Published online on: December 1, 2007     https://doi.org/10.3892/or.18.6.1563
  • Pages: 1563-1569
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Abstract

With the aim of determining the differential expression of WNT and FZD genes, before and after induction of apoptosis in BCR-ABL positive cells, we treated the myeloid cell line K562 and control cell line HL60 with imatinib mesylate and etoposide, and analyzed relative mRNA expression levels of WNT, FZD and sFRP genes under normal and apoptotic conditions by real-time RT-PCR. We observed marked increase in mRNA levels of FZD4, FZD5, FZD7 and WNT5b, correlating with apoptotic activity and independent of the agent or cell line used. Our results suggest the involvement of non-canonical Wnt signaling in executing programmed cell death in myeloid cell lines.

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December 2007
Volume 18 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sercan HO, Pehlivan M, Simsek O, Ates H and Sercan Z: Induction of apoptosis increases expression of non-canonical WNT genes in myeloid leukemia cell lines. Oncol Rep 18: 1563-1569, 2007
APA
Sercan, H.O., Pehlivan, M., Simsek, O., Ates, H., & Sercan, Z. (2007). Induction of apoptosis increases expression of non-canonical WNT genes in myeloid leukemia cell lines. Oncology Reports, 18, 1563-1569. https://doi.org/10.3892/or.18.6.1563
MLA
Sercan, H. O., Pehlivan, M., Simsek, O., Ates, H., Sercan, Z."Induction of apoptosis increases expression of non-canonical WNT genes in myeloid leukemia cell lines". Oncology Reports 18.6 (2007): 1563-1569.
Chicago
Sercan, H. O., Pehlivan, M., Simsek, O., Ates, H., Sercan, Z."Induction of apoptosis increases expression of non-canonical WNT genes in myeloid leukemia cell lines". Oncology Reports 18, no. 6 (2007): 1563-1569. https://doi.org/10.3892/or.18.6.1563