INHIBITION OF THE PROLIFERATION OF ANDROGEN-DEPENDENT SC-3 CELLS BY METHYLCOBALAMIN

  • Authors:
    • Y NISHIZAWA
    • T YAMAMOTO
    • N TERADA
    • B SATO
    • K MATSUMOTO
  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/or.2.1.129
  • Pages: 129-132
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Abstract

Methylcobalamin decreased the proliferation of androgen-dependent SC-3 cells, derived from androgen-dependent mouse mammary tumor SC115, in a dose dependent manner at high concentrations without remarkable change of the cell viability. The androgen-induced growth factor activity in the conditioned medium of SC-3 cells cultured in the presence of androgen was shown to be decreased by the addition of methylcobalamin. In SC-3 cells incubated with [methyl-H-3]methylcobalamin, [H-3]methyl moiety was incorporated into the DNA fraction. These results indicate an antiproliferative effect of methylcobalamin on SC-3 cells at high concentrations and suggest a possibility that methylcobalamin can act as a donor of methyl moiety into DNA.

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January 1995
Volume 2 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
NISHIZAWA Y, YAMAMOTO T, TERADA N, SATO B and MATSUMOTO K: INHIBITION OF THE PROLIFERATION OF ANDROGEN-DEPENDENT SC-3 CELLS BY METHYLCOBALAMIN. Oncol Rep 2: 129-132, 1995
APA
NISHIZAWA, Y., YAMAMOTO, T., TERADA, N., SATO, B., & MATSUMOTO, K. (1995). INHIBITION OF THE PROLIFERATION OF ANDROGEN-DEPENDENT SC-3 CELLS BY METHYLCOBALAMIN. Oncology Reports, 2, 129-132. https://doi.org/10.3892/or.2.1.129
MLA
NISHIZAWA, Y., YAMAMOTO, T., TERADA, N., SATO, B., MATSUMOTO, K."INHIBITION OF THE PROLIFERATION OF ANDROGEN-DEPENDENT SC-3 CELLS BY METHYLCOBALAMIN". Oncology Reports 2.1 (1995): 129-132.
Chicago
NISHIZAWA, Y., YAMAMOTO, T., TERADA, N., SATO, B., MATSUMOTO, K."INHIBITION OF THE PROLIFERATION OF ANDROGEN-DEPENDENT SC-3 CELLS BY METHYLCOBALAMIN". Oncology Reports 2, no. 1 (1995): 129-132. https://doi.org/10.3892/or.2.1.129