PREVENTION OF LIVER-TUMOR COLONIZATION BY COMBINED IMMUNOMODULATION AND LIVER LECTIN BLOCKING
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- Published online on: January 1, 1995 https://doi.org/10.3892/or.2.1.151
- Pages: 151-153
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Abstract
The protective effect of combined treatment (immunomodulation with Propionibacterium avidum KP-40; liver lectin blocking by D-galactose administration) on the liver colonization of RAW 117-H10 lymphosarcoma was investigated in BALB/c-mice. Both, immunomodulation with P. avidum KP-40 as well as liver lectin blocking by D-galactose treatment significantly decreased the number of liver tumor colonies in this experimental model. However, the combination of P. avidum KP-40 and D-galactose obviously proved to be superior to each monotherapy since the liver colonization by RAW 117-H 10 lymphosarcoma could be completely inhibited.