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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 1995 Volume 2 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1995 Volume 2 Issue 1

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Article

RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL

  • Authors:
    • SA SHEWEITA
    • MH MOSTAFA

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    Affiliations: Affliations not specified
  • Pages: 155-159
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    Published online on: January 1, 1995
       https://doi.org/10.3892/or.2.1.155
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Abstract

The influence of Schistosoma mansoni infection on the capacity of the carcinogen-metabolizing enzymes was investigated prior to and after treatment of the infected male mice with praziquantel, an anti-schistosomal agent. The drug was administered in a daily dose of 60 mg/kg body weight for three days before decapitation at various infection intervals. After 20 and 30 days post-infection the hepatic content of cytochrome P-450 and cytochrome b-5 and the activity of aryl hydrocarbon hydroxylase were markedly increased. However, the constitutive levels of the above mentioned enzymes were significantly decreased at 45, 60 and 75 days post-infection. Treatment of the infected mice with praziquantel for three days, however, recovered the changes in these activities at each individual time point. Praziquantel showed no effect on either of the studied enzymes when administered alone except for that of NADPH-cytochrome C reductase activity which exhibited significant increase. The activity of NADPH-cytochrome C reductase gave inconsistent results after treatment of the infected animals with praziquantel. It is concluded that praziquantel can be considered as a safe and useful drug for the chemotherapy of schistosomiasis and it possessed a recovery for the activities of the drug-metabolizing enzyme.

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Copy and paste a formatted citation
Spandidos Publications style
SHEWEITA S and MOSTAFA M: RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL. Oncol Rep 2: 155-159, 1995.
APA
SHEWEITA, S., & MOSTAFA, M. (1995). RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL. Oncology Reports, 2, 155-159. https://doi.org/10.3892/or.2.1.155
MLA
SHEWEITA, S., MOSTAFA, M."RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL". Oncology Reports 2.1 (1995): 155-159.
Chicago
SHEWEITA, S., MOSTAFA, M."RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL". Oncology Reports 2, no. 1 (1995): 155-159. https://doi.org/10.3892/or.2.1.155
Copy and paste a formatted citation
x
Spandidos Publications style
SHEWEITA S and MOSTAFA M: RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL. Oncol Rep 2: 155-159, 1995.
APA
SHEWEITA, S., & MOSTAFA, M. (1995). RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL. Oncology Reports, 2, 155-159. https://doi.org/10.3892/or.2.1.155
MLA
SHEWEITA, S., MOSTAFA, M."RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL". Oncology Reports 2.1 (1995): 155-159.
Chicago
SHEWEITA, S., MOSTAFA, M."RECOVERY OF THE HEPATIC CARCINOGEN-METABOLIZING CAPACITY IN SCHISTOSOME-INFECTED MICE AFTER TREATMENT WITH THE ANTISCHISTOSOMAL PRAZIQUANTEL". Oncology Reports 2, no. 1 (1995): 155-159. https://doi.org/10.3892/or.2.1.155
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