FOTEMUSTINE IN PATIENTS WITH RELAPSING MALIGNANT GLIOMAS - A PHASE-II TRIAL
- CJA PUNT
- L STAMATAKIS
- B GERARD
Affiliations: INST RECH INT SERV,BRUSSELS,BELGIUM. CTR HOSP TIVOLI,LA LOUVIERE,BELGIUM.
- Published online on: March 1, 1995 https://doi.org/10.3892/or.2.2.307
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Eleven patients with relapsing malignant glioma were treated with fotemustine chemotherapy, a new nitrosourea derivative. One partial response of 13 months duration occurred, resulting in a marked improvement of the quality of life of the patient. Seven patients had stable disease for a median duration of 5 months. Median survival from inclusion in the study was 6 months. Toxicity was mainly hematologic and manageable. We confirm that fotemustine has some activity in patients with relapsing malignant glioma.