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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 1995 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1995 Volume 2 Issue 3

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Article

EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES

  • Authors:
    • R YOSHIKAWA
    • S ICHII
    • T HASHIMOTO
    • JI FURUYAMA
    • J UTSUNOMIYA

  • View Affiliations / Copyright

    Affiliations: HYOGO MED UNIV,DEPT GENET,NISHINOMIYA,HYOGO 663,JAPAN.
  • Pages: 361-364
    |
    Published online on: May 1, 1995
       https://doi.org/10.3892/or.2.3.361
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Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit experimental carcinogenesis and their use in humans has been related epidemiologically to a reduced risk of colorectal polyps and cancer, although the mechanism involved is not known. We found that aspirin triggered the death of SW948 human colorectal adenocarcinoma cells through activation of an apoptotic pathway. Exposure of SW480 and SW948 cells to 25 mu M aspirin for 5 h resulted in the detatchment of cells from the monolayer culture at 48 h. SW948 cells with continuous exposure to 25 mu M aspirin exhibited various morphological and biochemical characteristics of apoptosis, including compact patches of condensed nuclear chromatin, and DNA fragmentation. These in vitro data suggest that apoptosis may play a role in the antitumor effect of aspirin and other NSAIDs and that the induction of apoptosis may provide an attractive therapeutic target in colorectal carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
YOSHIKAWA R, ICHII S, HASHIMOTO T, FURUYAMA J and UTSUNOMIYA J: EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES. Oncol Rep 2: 361-364, 1995.
APA
YOSHIKAWA, R., ICHII, S., HASHIMOTO, T., FURUYAMA, J., & UTSUNOMIYA, J. (1995). EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES. Oncology Reports, 2, 361-364. https://doi.org/10.3892/or.2.3.361
MLA
YOSHIKAWA, R., ICHII, S., HASHIMOTO, T., FURUYAMA, J., UTSUNOMIYA, J."EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES". Oncology Reports 2.3 (1995): 361-364.
Chicago
YOSHIKAWA, R., ICHII, S., HASHIMOTO, T., FURUYAMA, J., UTSUNOMIYA, J."EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES". Oncology Reports 2, no. 3 (1995): 361-364. https://doi.org/10.3892/or.2.3.361
Copy and paste a formatted citation
x
Spandidos Publications style
YOSHIKAWA R, ICHII S, HASHIMOTO T, FURUYAMA J and UTSUNOMIYA J: EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES. Oncol Rep 2: 361-364, 1995.
APA
YOSHIKAWA, R., ICHII, S., HASHIMOTO, T., FURUYAMA, J., & UTSUNOMIYA, J. (1995). EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES. Oncology Reports, 2, 361-364. https://doi.org/10.3892/or.2.3.361
MLA
YOSHIKAWA, R., ICHII, S., HASHIMOTO, T., FURUYAMA, J., UTSUNOMIYA, J."EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES". Oncology Reports 2.3 (1995): 361-364.
Chicago
YOSHIKAWA, R., ICHII, S., HASHIMOTO, T., FURUYAMA, J., UTSUNOMIYA, J."EFFECT OF ASPIRIN ON THE INDUCTION OF APOPTOSIS IN COLORECTAL ADENOCARCINOMA CELL-LINES". Oncology Reports 2, no. 3 (1995): 361-364. https://doi.org/10.3892/or.2.3.361
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