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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 1995 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1995 Volume 2 Issue 3

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Article

MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT

  • Authors:
    • DJH ROBERTS
    • F CAIRNDUFF
    • B DIXON
    • SB BROWN

  • View Affiliations / Copyright

    Affiliations: UNIV LEEDS,DEPT BIOCHEM & MOLEC BIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND.
  • Pages: 387-390
    |
    Published online on: May 1, 1995
       https://doi.org/10.3892/or.2.3.387
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Abstract

The ability of hyperbaric oxygen (HBO) treatment to modulate the response of a rodent fibrosarcoma to interstitial photodynamic therapy (PDT) using 630 nm light and intravenous polyhaematoporphyrin (PHP) was examined. Application of HBO for 30 min immediately prior to PDT resulted in a light dose-dependent increase in tumour growth retardation, maximum effect (+227%) being observed with 100J light, and no enhancement being seen at or above 400J. Application of HBO during or immediately after PDT had no effect on response. Reducing the interval between giving PHP and administering light from the usual 48 h to just 1 h increased the efficacy of PDT even in the absence of HBO pre-treatment. Under these circumstances, application of HBO did not realise any further increase in tumour response at any light dose. Our findings suggest that manipulation of tumour oxygenation may be able to improve the outcome of PDT under some circumstances, but that careful consideration of other treatment variables, such as light dose and drug-to-light interval, may provide similar, more easily achievable, improvements in efficacy.

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Copy and paste a formatted citation
Spandidos Publications style
ROBERTS D, CAIRNDUFF F, DIXON B and BROWN S: MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT. Oncol Rep 2: 387-390, 1995.
APA
ROBERTS, D., CAIRNDUFF, F., DIXON, B., & BROWN, S. (1995). MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT. Oncology Reports, 2, 387-390. https://doi.org/10.3892/or.2.3.387
MLA
ROBERTS, D., CAIRNDUFF, F., DIXON, B., BROWN, S."MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT". Oncology Reports 2.3 (1995): 387-390.
Chicago
ROBERTS, D., CAIRNDUFF, F., DIXON, B., BROWN, S."MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT". Oncology Reports 2, no. 3 (1995): 387-390. https://doi.org/10.3892/or.2.3.387
Copy and paste a formatted citation
x
Spandidos Publications style
ROBERTS D, CAIRNDUFF F, DIXON B and BROWN S: MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT. Oncol Rep 2: 387-390, 1995.
APA
ROBERTS, D., CAIRNDUFF, F., DIXON, B., & BROWN, S. (1995). MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT. Oncology Reports, 2, 387-390. https://doi.org/10.3892/or.2.3.387
MLA
ROBERTS, D., CAIRNDUFF, F., DIXON, B., BROWN, S."MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT". Oncology Reports 2.3 (1995): 387-390.
Chicago
ROBERTS, D., CAIRNDUFF, F., DIXON, B., BROWN, S."MODULATION OF THE RESPONSE OF A RODENT FIBROSARCOMA TO PHOTODYNAMIC THERAPY BY HYPERBARIC-OXYGEN TREATMENT". Oncology Reports 2, no. 3 (1995): 387-390. https://doi.org/10.3892/or.2.3.387
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