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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 1995 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1995 Volume 2 Issue 3

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Article

ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER

  • Authors:
    • H KIARIS
    • AG ELIOPOULOS
    • E SIVRIDIS
    • M ERGAZAKI
    • DA SPANDIDOS

  • View Affiliations / Copyright

    Affiliations: NATL HELLEN RES FDN,INST BIOL RES & BIOTECHNOL,GR-11635 ATHENS,GREECE. UNIV CRETE,SCH MED,IRAKLION,GREECE. UNIV BIRMINGHAM,SCH MED,CRC,INST CANC STUDIES,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND. DEMOCRITUS UNIV THRACE,SCH MED,ALEXANDROUPOLIS,GREECE.
  • Pages: 427-430
    |
    Published online on: May 1, 1995
       https://doi.org/10.3892/or.2.3.427
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Abstract

ras family genes (H-, K- and N-ras) encode for a 21 kD membrane protein which possesses GTPase activity and participates in a signal transduction pathway. Activating mutations of the ras family genes occur at codons 12, 13 and 61 and have been detected in a variety of human tumours, including colonic, bladder and pancreatic cancers. Prostatic cancer is among the most common malignancies throughout the world and a major cause of death from cancer in males. Data reported on the implication of the ras family genes in the development of the disease are conflicting. The aim of this study was to determine the incidence of mutations at codon 12 of H-ras, codon 12 of K-ras and codon 61 of N-ras proto-oncogenes, in a Greek population with prostatic cancer. Our analysis revealed that 4 out of 20 (20%) samples harboured a K-ras codon 12 point mutation, 1 out of 20 (5%) specimens contained mutations at codon 12 of the H-ras and 1 out of 20 (5%) at codon 61 of the N-ras, indicating a role for the ras genes in the development of the disease.

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Copy and paste a formatted citation
Spandidos Publications style
KIARIS H, ELIOPOULOS A, SIVRIDIS E, ERGAZAKI M and SPANDIDOS D: ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER. Oncol Rep 2: 427-430, 1995.
APA
KIARIS, H., ELIOPOULOS, A., SIVRIDIS, E., ERGAZAKI, M., & SPANDIDOS, D. (1995). ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER. Oncology Reports, 2, 427-430. https://doi.org/10.3892/or.2.3.427
MLA
KIARIS, H., ELIOPOULOS, A., SIVRIDIS, E., ERGAZAKI, M., SPANDIDOS, D."ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER". Oncology Reports 2.3 (1995): 427-430.
Chicago
KIARIS, H., ELIOPOULOS, A., SIVRIDIS, E., ERGAZAKI, M., SPANDIDOS, D."ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER". Oncology Reports 2, no. 3 (1995): 427-430. https://doi.org/10.3892/or.2.3.427
Copy and paste a formatted citation
x
Spandidos Publications style
KIARIS H, ELIOPOULOS A, SIVRIDIS E, ERGAZAKI M and SPANDIDOS D: ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER. Oncol Rep 2: 427-430, 1995.
APA
KIARIS, H., ELIOPOULOS, A., SIVRIDIS, E., ERGAZAKI, M., & SPANDIDOS, D. (1995). ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER. Oncology Reports, 2, 427-430. https://doi.org/10.3892/or.2.3.427
MLA
KIARIS, H., ELIOPOULOS, A., SIVRIDIS, E., ERGAZAKI, M., SPANDIDOS, D."ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER". Oncology Reports 2.3 (1995): 427-430.
Chicago
KIARIS, H., ELIOPOULOS, A., SIVRIDIS, E., ERGAZAKI, M., SPANDIDOS, D."ACTIVATING MUTATIONS OF RAS FAMILY GENES IN PROSTATIC-CANCER". Oncology Reports 2, no. 3 (1995): 427-430. https://doi.org/10.3892/or.2.3.427
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