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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 1995 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1995 Volume 2 Issue 3

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Article

APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA

  • Authors:
    • V VISHLITZKY
    • R NESSABRAMOF
    • R ZEMER
    • M ELLIS
    • M LISHNER
    • Y MANOR
    • MS YUKLEA
    • A KLEIN

  • View Affiliations / Copyright

    Affiliations: BAR ILAN UNIV,SAPIR MED CTR,DEPT LIFE SCI,MOLEC BIOL LAB,IL-44281 KEFAR SAVA,ISRAEL. TEL AVIV UNIV,SAPIR MED CTR,SACKLER SCH MED,DEPT MED C,IL-44281 KEFAR SAVA,ISRAEL. TEL AVIV UNIV,SAPIR MED CTR,SACKLER SCH MED,HEMATOL UNIT,IL-44281 KEFAR SAVA,ISRAEL.
  • Pages: 461-463
    |
    Published online on: May 1, 1995
       https://doi.org/10.3892/or.2.3.461
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Abstract

Apoptosis, programmed cell death, occurs in a variety of cellular systems and in response to many different stimuli. One group of apoptosis inducers are glucocorticosteroids which are also found in the battery of cytotoxic drugs used to treat CLL. In the present study we have examined the potency of the glucocorticosteroid-dexamethasone to induce apoptosis in lymphocytes of patients with B-CLL. Lymphocytes of 15 nontreated patients and 5 controls were isolated and incubated for 24 h in the presence or absence of dexamethasone (2 mu M) Following incubation the cells were harvested and their DNA extracted. The extracted DNA samples were analysed for internucleosomal DNA cleavage by UV illumination after electrophoresis on agarose slab gel containing ethidium bromide. Five patients showed neither spontaneous nor dexamethasone induced apoptosis. Whereas, 10 patients, showed a dexamethasone-non-dependent spontaneous apoptosis which appeared 24 h after the start of incubation. The cells of these patients were the only ones to respond to dexamethasone showing an enhanced apoptosis effect. This study shows that apoptosis monitoring in CLL may provide important information regarding susceptibility of the cells to steroid induced apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
VISHLITZKY V, NESSABRAMOF R, ZEMER R, ELLIS M, LISHNER M, MANOR Y, YUKLEA M and KLEIN A: APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA. Oncol Rep 2: 461-463, 1995.
APA
VISHLITZKY, V., NESSABRAMOF, R., ZEMER, R., ELLIS, M., LISHNER, M., MANOR, Y. ... KLEIN, A. (1995). APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA. Oncology Reports, 2, 461-463. https://doi.org/10.3892/or.2.3.461
MLA
VISHLITZKY, V., NESSABRAMOF, R., ZEMER, R., ELLIS, M., LISHNER, M., MANOR, Y., YUKLEA, M., KLEIN, A."APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA". Oncology Reports 2.3 (1995): 461-463.
Chicago
VISHLITZKY, V., NESSABRAMOF, R., ZEMER, R., ELLIS, M., LISHNER, M., MANOR, Y., YUKLEA, M., KLEIN, A."APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA". Oncology Reports 2, no. 3 (1995): 461-463. https://doi.org/10.3892/or.2.3.461
Copy and paste a formatted citation
x
Spandidos Publications style
VISHLITZKY V, NESSABRAMOF R, ZEMER R, ELLIS M, LISHNER M, MANOR Y, YUKLEA M and KLEIN A: APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA. Oncol Rep 2: 461-463, 1995.
APA
VISHLITZKY, V., NESSABRAMOF, R., ZEMER, R., ELLIS, M., LISHNER, M., MANOR, Y. ... KLEIN, A. (1995). APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA. Oncology Reports, 2, 461-463. https://doi.org/10.3892/or.2.3.461
MLA
VISHLITZKY, V., NESSABRAMOF, R., ZEMER, R., ELLIS, M., LISHNER, M., MANOR, Y., YUKLEA, M., KLEIN, A."APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA". Oncology Reports 2.3 (1995): 461-463.
Chicago
VISHLITZKY, V., NESSABRAMOF, R., ZEMER, R., ELLIS, M., LISHNER, M., MANOR, Y., YUKLEA, M., KLEIN, A."APOPTOSIS AS AN INDICATOR FOR STEROID SENSITIVITY OF LYMPHOCYTES IN B-CHRONIC LYMPHOCYTIC-LEUKEMIA". Oncology Reports 2, no. 3 (1995): 461-463. https://doi.org/10.3892/or.2.3.461
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