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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 1995 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1995 Volume 2 Issue 3

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Article

DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA

  • Authors:
    • K SURESH
    • KK JAYAVARDHANAN
    • K NIRMALA
    • DM VASUDEVAN

  • View Affiliations / Copyright

    Affiliations: COLL MED,DEPT BIOCHEM,TRICHUR 680596,KERALA,INDIA. INST CANC RES,MADRAS 600020,TAMIL NADU,INDIA.
  • Pages: 481-485
    |
    Published online on: May 1, 1995
       https://doi.org/10.3892/or.2.3.481
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Abstract

The relationship between IL-2-R gene transcription and natural cell mediated cytotoxicity (NKCMC) in the peripheral blood lymphocytes of 15 patients with gastric carcinoma and 6 normal healthy controls were studied. NKCMC and ADCC assessed against radiolabelled K-562 and sensitized chicken RBC as respective target cells in Cr-51 release assay revealed significant reduction in patients as compared to controls. The impairment in the natural cytotoxicity was associated with decreased IL-2-R gene expression at the mRNA level in these patients. Expression of both IL-2 R alpha transcripts (3.5 and 1.5 Kb) were either not detectable or only weakly detectable on T lymphocytes from patients even after mitogenic stimulation. In contrast, a significant rise in the expression of both IL-2 R alpha transcripts was observed on T cells from normal controls followed by mitogenic challenge. We interpret our findings to reflect the direct correlation between NKCMC and IL-2-R gene transcription in gastric carcinoma patients.

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Copy and paste a formatted citation
Spandidos Publications style
SURESH K, JAYAVARDHANAN K, NIRMALA K and VASUDEVAN D: DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA. Oncol Rep 2: 481-485, 1995.
APA
SURESH, K., JAYAVARDHANAN, K., NIRMALA, K., & VASUDEVAN, D. (1995). DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA. Oncology Reports, 2, 481-485. https://doi.org/10.3892/or.2.3.481
MLA
SURESH, K., JAYAVARDHANAN, K., NIRMALA, K., VASUDEVAN, D."DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA". Oncology Reports 2.3 (1995): 481-485.
Chicago
SURESH, K., JAYAVARDHANAN, K., NIRMALA, K., VASUDEVAN, D."DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA". Oncology Reports 2, no. 3 (1995): 481-485. https://doi.org/10.3892/or.2.3.481
Copy and paste a formatted citation
x
Spandidos Publications style
SURESH K, JAYAVARDHANAN K, NIRMALA K and VASUDEVAN D: DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA. Oncol Rep 2: 481-485, 1995.
APA
SURESH, K., JAYAVARDHANAN, K., NIRMALA, K., & VASUDEVAN, D. (1995). DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA. Oncology Reports, 2, 481-485. https://doi.org/10.3892/or.2.3.481
MLA
SURESH, K., JAYAVARDHANAN, K., NIRMALA, K., VASUDEVAN, D."DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA". Oncology Reports 2.3 (1995): 481-485.
Chicago
SURESH, K., JAYAVARDHANAN, K., NIRMALA, K., VASUDEVAN, D."DIRECT CORRELATION BETWEEN IL-2-R GENE-TRANSCRIPTION AND NATURAL CELL-MEDIATED CYTOTOXICITY IN PATIENTS WITH GASTRIC-CARCINOMA". Oncology Reports 2, no. 3 (1995): 481-485. https://doi.org/10.3892/or.2.3.481
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