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EFFECTS OF TNP-470 (AGM-1470) ON TUMOR-GROWTH, ANGIOGENESIS AND SERUM COPPER LEVELS IN LIVER-CANCER BEARING RATS

  • Authors:
    • S MATSUOKA
    • J UCHINO
    • Y UNE
    • H ISHIMURA
    • S TSUCHIMOTO
    • T KAMIYAMA

  • View Affiliations

  • Published online on: July 1, 1995     https://doi.org/10.3892/or.2.4.583
  • Pages: 583-589
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Abstract

Administration of TNP-470 (AGM-1470), a newly developed angiogenesis inhibitor, elevated serum copper concentrations (SCu) in a dose-dependent manner in normal rats as well as tumor-bearing rats. After discontinuation of TNP-470, SCu returned to the normal range in normal rats. In tumor-bearing rats, however, SCu decreased and then became elevated in relation to the tumor growth and capillary density in this hepatic tumor. The mechanisms leading to serum copper elevation may reflect a specific pharmacologic action of TNP-470, though it may also be related to tumor growth and reactivation of tumor angiogenesis after cessation of TNP-470.

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July 1995
Volume 2 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
MATSUOKA S, UCHINO J, UNE Y, ISHIMURA H, TSUCHIMOTO S and KAMIYAMA T: EFFECTS OF TNP-470 (AGM-1470) ON TUMOR-GROWTH, ANGIOGENESIS AND SERUM COPPER LEVELS IN LIVER-CANCER BEARING RATS. Oncol Rep 2: 583-589, 1995
APA
MATSUOKA, S., UCHINO, J., UNE, Y., ISHIMURA, H., TSUCHIMOTO, S., & KAMIYAMA, T. (1995). EFFECTS OF TNP-470 (AGM-1470) ON TUMOR-GROWTH, ANGIOGENESIS AND SERUM COPPER LEVELS IN LIVER-CANCER BEARING RATS. Oncology Reports, 2, 583-589. https://doi.org/10.3892/or.2.4.583
MLA
MATSUOKA, S., UCHINO, J., UNE, Y., ISHIMURA, H., TSUCHIMOTO, S., KAMIYAMA, T."EFFECTS OF TNP-470 (AGM-1470) ON TUMOR-GROWTH, ANGIOGENESIS AND SERUM COPPER LEVELS IN LIVER-CANCER BEARING RATS". Oncology Reports 2.4 (1995): 583-589.
Chicago
MATSUOKA, S., UCHINO, J., UNE, Y., ISHIMURA, H., TSUCHIMOTO, S., KAMIYAMA, T."EFFECTS OF TNP-470 (AGM-1470) ON TUMOR-GROWTH, ANGIOGENESIS AND SERUM COPPER LEVELS IN LIVER-CANCER BEARING RATS". Oncology Reports 2, no. 4 (1995): 583-589. https://doi.org/10.3892/or.2.4.583