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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1995 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1995 Volume 2 Issue 4

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Article

PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA

  • Authors:
    • M COLLEONI
    • M DIBARTOLOMEO
    • E BAJETTA
    • F NOLE
    • P NELLI
    • C CARNAGHI
    • G VICARIO
    • M DELVECCHIO
    • A BONO

  • View Affiliations / Copyright

    Affiliations: IST NAZL TUMORI,DIV MED ONCOL B,I-20133 MILAN,ITALY.
  • Pages: 603-606
    |
    Published online on: July 1, 1995
       https://doi.org/10.3892/or.2.4.603
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Abstract

Systemic chemotherapy with currently available agents in unresectable HCC has a minimal impact on disease progression and a predictable response rate of <20%. Doxifluridine (5 deoxy-5-fluorouridine, dFUR) is a new fluropyrimidine derivative that demonstrated higher antitumoral activity than other fluoropyrimidines in murine tumors and optimal gastrointestinal absorption when administered orally. Therefore, we evaluated the activity and feasibility of a combination of dFUR and l-leucovorin in unresectable HCC by the following schedule: l-leucovorin 25 mg orally followed 2 hours later by dFUR 1,200 mg/m(2), day 1 through 5, cycles being repeated every 10 days. Thirtyseven patients with unresectable HCC entered the study and are evaluable for response and toxicity. Three partial responses have been observed, to a global response rate of 8% (95% confidence interval 2-22%). After a median observation time of 12 months, the median survival was 7 months, with a median time to progression of 4 months; Main toxicity was diarrhea; severe in 30% of the patients. One patient died as a result of uncontrollable diarrhea. In view of the limited activity observed, further trials with this schedule are not warranted.

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Copy and paste a formatted citation
Spandidos Publications style
COLLEONI M, DIBARTOLOMEO M, BAJETTA E, NOLE F, NELLI P, CARNAGHI C, VICARIO G, DELVECCHIO M and BONO A: PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA. Oncol Rep 2: 603-606, 1995.
APA
COLLEONI, M., DIBARTOLOMEO, M., BAJETTA, E., NOLE, F., NELLI, P., CARNAGHI, C. ... BONO, A. (1995). PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA. Oncology Reports, 2, 603-606. https://doi.org/10.3892/or.2.4.603
MLA
COLLEONI, M., DIBARTOLOMEO, M., BAJETTA, E., NOLE, F., NELLI, P., CARNAGHI, C., VICARIO, G., DELVECCHIO, M., BONO, A."PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA". Oncology Reports 2.4 (1995): 603-606.
Chicago
COLLEONI, M., DIBARTOLOMEO, M., BAJETTA, E., NOLE, F., NELLI, P., CARNAGHI, C., VICARIO, G., DELVECCHIO, M., BONO, A."PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA". Oncology Reports 2, no. 4 (1995): 603-606. https://doi.org/10.3892/or.2.4.603
Copy and paste a formatted citation
x
Spandidos Publications style
COLLEONI M, DIBARTOLOMEO M, BAJETTA E, NOLE F, NELLI P, CARNAGHI C, VICARIO G, DELVECCHIO M and BONO A: PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA. Oncol Rep 2: 603-606, 1995.
APA
COLLEONI, M., DIBARTOLOMEO, M., BAJETTA, E., NOLE, F., NELLI, P., CARNAGHI, C. ... BONO, A. (1995). PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA. Oncology Reports, 2, 603-606. https://doi.org/10.3892/or.2.4.603
MLA
COLLEONI, M., DIBARTOLOMEO, M., BAJETTA, E., NOLE, F., NELLI, P., CARNAGHI, C., VICARIO, G., DELVECCHIO, M., BONO, A."PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA". Oncology Reports 2.4 (1995): 603-606.
Chicago
COLLEONI, M., DIBARTOLOMEO, M., BAJETTA, E., NOLE, F., NELLI, P., CARNAGHI, C., VICARIO, G., DELVECCHIO, M., BONO, A."PHASE-II TRIAL OF ORAL DOXIFLURIDINE PLUS ORAL LEVO-LEUCOVORIN IN UNRESECTABLE HEPATOCELLULAR-CARCINOMA". Oncology Reports 2, no. 4 (1995): 603-606. https://doi.org/10.3892/or.2.4.603
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