1-O-OCTADECYL-2-O-METHYL-GLYCEROPHOSPHOSCHOLINE INHIBITS THE ADHESION OF RAS-TRANSFORMED FIBROBLASTS TO HUMAN ENDOTHELIAL-CELLS

  • Authors:
    • P SAMADDER
    • XL LU
    • G ARTHUR
  • View Affiliations

  • Published online on: July 1, 1995     https://doi.org/10.3892/or.2.4.647
  • Pages: 647-650
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Abstract

The adhesion of tumor cells to the endothelium is a key step in haematogenic metastasis. Because alkyllysophospholipids decrease tumor metastasis, we investigated the effect of 1-O-octadecyl-2-O-methyl-glycerophosphocholine (ET18-OCH3) on the adhesion of two highly metastatic ras-transformed 10T1/2 cell lines, CIRAS-2 and CIRAS-3, to confluent endothelial cells. The order of adhesion to the endothelial cells was CIRAS-2 > 10T1/2 > CIRAS-3. RGD peptides were unable to inhibit the binding of the cells suggesting that adhesion was not mediated by fibronectin or vitronectin. Treatment of the cell lines with 20 mu M ET18-OCH3 for 24 h decreased the adhesion of CIRAS-2, CIRAS-3 and 10T1/2 to the endothelial cells by 50, 43 and 36% respectively. Thus interference in the adhesion of tumor cells to the endothelium could contribute to decreased metastasis.

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July 1995
Volume 2 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
SAMADDER P, LU X and ARTHUR G: 1-O-OCTADECYL-2-O-METHYL-GLYCEROPHOSPHOSCHOLINE INHIBITS THE ADHESION OF RAS-TRANSFORMED FIBROBLASTS TO HUMAN ENDOTHELIAL-CELLS. Oncol Rep 2: 647-650, 1995
APA
SAMADDER, P., LU, X., & ARTHUR, G. (1995). 1-O-OCTADECYL-2-O-METHYL-GLYCEROPHOSPHOSCHOLINE INHIBITS THE ADHESION OF RAS-TRANSFORMED FIBROBLASTS TO HUMAN ENDOTHELIAL-CELLS. Oncology Reports, 2, 647-650. https://doi.org/10.3892/or.2.4.647
MLA
SAMADDER, P., LU, X., ARTHUR, G."1-O-OCTADECYL-2-O-METHYL-GLYCEROPHOSPHOSCHOLINE INHIBITS THE ADHESION OF RAS-TRANSFORMED FIBROBLASTS TO HUMAN ENDOTHELIAL-CELLS". Oncology Reports 2.4 (1995): 647-650.
Chicago
SAMADDER, P., LU, X., ARTHUR, G."1-O-OCTADECYL-2-O-METHYL-GLYCEROPHOSPHOSCHOLINE INHIBITS THE ADHESION OF RAS-TRANSFORMED FIBROBLASTS TO HUMAN ENDOTHELIAL-CELLS". Oncology Reports 2, no. 4 (1995): 647-650. https://doi.org/10.3892/or.2.4.647