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CROSS-RESISTANCE TO ANTINEOPLASTIC AGENTS IN A HUMAN SMALL-CELL LUNG-CANCER SUBLINE RESISTANT TO OKADAIC ACID

  • Authors:
    • Y TAKEDA
    • N KUBOTA
    • K NISHIO
    • Y FUNAYAMA
    • A GEMMA
    • H NIITANI
    • N SAIJO

  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/or.2.5.705
  • Pages: 705-710
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We report on a human small cell lung cancer subline (H69/OA100) resistant to okadaic acid, an inhibitor of protein phosphatases. H69/OA100 showed cross-resistance to cis-diamminedichloroplatinum(II) (CDDP), adriamycin, and vinca alkaloids. Intracellular retention of adriamycin and CDDP in H69/OA100 was the same as those in H69. H69/OA100 was not shown to express MDR-1 by the reverse transcription polymerase chain reaction method. Expression level of mRNA of multidrug resistance-associated protein (MRP) in H69/OA100 was the same as that in H69. These data suggest that the mechanism of drug resistance in H69/OA100 might be due to a new mechanism of non-P-glycoprotein mediated multidrug resistance.

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September 1995
Volume 2 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
TAKEDA Y, KUBOTA N, NISHIO K, FUNAYAMA Y, GEMMA A, NIITANI H and SAIJO N: CROSS-RESISTANCE TO ANTINEOPLASTIC AGENTS IN A HUMAN SMALL-CELL LUNG-CANCER SUBLINE RESISTANT TO OKADAIC ACID. Oncol Rep 2: 705-710, 1995
APA
TAKEDA, Y., KUBOTA, N., NISHIO, K., FUNAYAMA, Y., GEMMA, A., NIITANI, H., & SAIJO, N. (1995). CROSS-RESISTANCE TO ANTINEOPLASTIC AGENTS IN A HUMAN SMALL-CELL LUNG-CANCER SUBLINE RESISTANT TO OKADAIC ACID. Oncology Reports, 2, 705-710. https://doi.org/10.3892/or.2.5.705
MLA
TAKEDA, Y., KUBOTA, N., NISHIO, K., FUNAYAMA, Y., GEMMA, A., NIITANI, H., SAIJO, N."CROSS-RESISTANCE TO ANTINEOPLASTIC AGENTS IN A HUMAN SMALL-CELL LUNG-CANCER SUBLINE RESISTANT TO OKADAIC ACID". Oncology Reports 2.5 (1995): 705-710.
Chicago
TAKEDA, Y., KUBOTA, N., NISHIO, K., FUNAYAMA, Y., GEMMA, A., NIITANI, H., SAIJO, N."CROSS-RESISTANCE TO ANTINEOPLASTIC AGENTS IN A HUMAN SMALL-CELL LUNG-CANCER SUBLINE RESISTANT TO OKADAIC ACID". Oncology Reports 2, no. 5 (1995): 705-710. https://doi.org/10.3892/or.2.5.705