PATHOLOGICAL AND ENZYMATIC FEATURES OF 1,2-DIMETHYLHYDRAZINE INDUCED COLORECTAL CARCINOMAS IN RATS

  • Authors:
    • S SUZUKI
    • I OKAYASU
    • H KUDA
    • K KUWA
    • S YOSHIMURA
    • T MITAMURA
    • S SAKAMOTO
  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/or.2.5.723
  • Pages: 723-726
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Abstract

Well- and moderately well-differentiated colorectal adenocarcinomas accounted for 86% of all tumors induced by 1,2-dimethylhydrazine in rats, and were distributed throughout the colorectal tract. Poorly differentiated carcinomas, 14% of all tumors, were markedly restricted to the proximal half of colon, i.e., 94% of the poorly differentiated type was found in the proximal colon and caecum. Thymidylate synthetase and thymidine kinase, key enzymes in the de novo and salvage pathways, respectively, for pyrimidine nucleotide synthesis were found to be reduced and elevated, respectively, with increasing cellular differentiation. These results suggest that biochemical differences in colorectal tumors may be associated with differences in tumor frequency, distribution, and histological type.

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September 1995
Volume 2 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
SUZUKI S, OKAYASU I, KUDA H, KUWA K, YOSHIMURA S, MITAMURA T and SAKAMOTO S: PATHOLOGICAL AND ENZYMATIC FEATURES OF 1,2-DIMETHYLHYDRAZINE INDUCED COLORECTAL CARCINOMAS IN RATS. Oncol Rep 2: 723-726, 1995
APA
SUZUKI, S., OKAYASU, I., KUDA, H., KUWA, K., YOSHIMURA, S., MITAMURA, T., & SAKAMOTO, S. (1995). PATHOLOGICAL AND ENZYMATIC FEATURES OF 1,2-DIMETHYLHYDRAZINE INDUCED COLORECTAL CARCINOMAS IN RATS. Oncology Reports, 2, 723-726. https://doi.org/10.3892/or.2.5.723
MLA
SUZUKI, S., OKAYASU, I., KUDA, H., KUWA, K., YOSHIMURA, S., MITAMURA, T., SAKAMOTO, S."PATHOLOGICAL AND ENZYMATIC FEATURES OF 1,2-DIMETHYLHYDRAZINE INDUCED COLORECTAL CARCINOMAS IN RATS". Oncology Reports 2.5 (1995): 723-726.
Chicago
SUZUKI, S., OKAYASU, I., KUDA, H., KUWA, K., YOSHIMURA, S., MITAMURA, T., SAKAMOTO, S."PATHOLOGICAL AND ENZYMATIC FEATURES OF 1,2-DIMETHYLHYDRAZINE INDUCED COLORECTAL CARCINOMAS IN RATS". Oncology Reports 2, no. 5 (1995): 723-726. https://doi.org/10.3892/or.2.5.723