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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 1995 Volume 2 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1995 Volume 2 Issue 5

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Article

SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS

  • Authors:
    • B KLEIN
    • I LEVIN
    • B KFIR
    • R MARINSKI
    • E RAKOWSKI
    • J SHAPIRA
    • R WEIL
    • M MISHAELI
    • T KLEIN

  • View Affiliations / Copyright

    Affiliations: GOLDA MEIR MED CTR,ONCOL UNIT,PETAH TIQWA,ISRAEL. GOLDA MEIR MED CTR,DEPT SURG,PETAH TIQWA,ISRAEL. SOROKA HOSP,DEPT UROL,BEER SHEVA,ISRAEL. BEILINSON MED CTR,TISSUE TYPING LAB,PETAH TIQWA,ISRAEL. BEILINSON MED CTR,DEPT ONCOL,PETAH TIQWA,ISRAEL. MEIR HOSP,ONCOL UNIT,KEFAR SAVA,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL.
  • Pages: 759-761
    |
    Published online on: September 1, 1995
       https://doi.org/10.3892/or.2.5.759
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Abstract

Serum levels of P185-HER-2 were measured in 137 breast cancer patients and in 40 controls. The patients were divided into 4 groups: group A - 40 newly diagnosed patients; group B - 57 patients on long-term follow-up without active disease; group C - 26 patients with metastatic disease and group D - 5 patients with locally advanced inoperable tumors. The median level in controls was 4.8 U/l. The median P185 serum levels in groups C and D were significantly higher compared to groups A and B. In group C 60% and in group D 100% of patients had baseline elevated levels of serum P185 (>5 U/l) compared to 28% in groups A and B. Of the 14 patients in group A with elevated baseline levels of serum P185, 6 (43%) developed metastasis during the 24-month follow-up period. On serial measurements during follow-up in 23 patients of group A, 3 relapsed and the P185 level increased. In group C, serial measurements in patients with elevated baseline levels of P185 correlated with clinical response to therapy. These data suggest that serum levels of P185 are elevated in patients with metastatic disease. High initial P185 serum levels in new patients may have prognostic significance. Serial measurements of P185 in asymptomatic patients may help in monitoring disease state. In metastatic patients, serial P185 determination may be of benefit in assessing response to therapy.

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Copy and paste a formatted citation
Spandidos Publications style
KLEIN B, LEVIN I, KFIR B, MARINSKI R, RAKOWSKI E, SHAPIRA J, WEIL R, MISHAELI M and KLEIN T: SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS. Oncol Rep 2: 759-761, 1995.
APA
KLEIN, B., LEVIN, I., KFIR, B., MARINSKI, R., RAKOWSKI, E., SHAPIRA, J. ... KLEIN, T. (1995). SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS. Oncology Reports, 2, 759-761. https://doi.org/10.3892/or.2.5.759
MLA
KLEIN, B., LEVIN, I., KFIR, B., MARINSKI, R., RAKOWSKI, E., SHAPIRA, J., WEIL, R., MISHAELI, M., KLEIN, T."SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS". Oncology Reports 2.5 (1995): 759-761.
Chicago
KLEIN, B., LEVIN, I., KFIR, B., MARINSKI, R., RAKOWSKI, E., SHAPIRA, J., WEIL, R., MISHAELI, M., KLEIN, T."SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS". Oncology Reports 2, no. 5 (1995): 759-761. https://doi.org/10.3892/or.2.5.759
Copy and paste a formatted citation
x
Spandidos Publications style
KLEIN B, LEVIN I, KFIR B, MARINSKI R, RAKOWSKI E, SHAPIRA J, WEIL R, MISHAELI M and KLEIN T: SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS. Oncol Rep 2: 759-761, 1995.
APA
KLEIN, B., LEVIN, I., KFIR, B., MARINSKI, R., RAKOWSKI, E., SHAPIRA, J. ... KLEIN, T. (1995). SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS. Oncology Reports, 2, 759-761. https://doi.org/10.3892/or.2.5.759
MLA
KLEIN, B., LEVIN, I., KFIR, B., MARINSKI, R., RAKOWSKI, E., SHAPIRA, J., WEIL, R., MISHAELI, M., KLEIN, T."SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS". Oncology Reports 2.5 (1995): 759-761.
Chicago
KLEIN, B., LEVIN, I., KFIR, B., MARINSKI, R., RAKOWSKI, E., SHAPIRA, J., WEIL, R., MISHAELI, M., KLEIN, T."SOLUBLE C-ERBB-2 (P185) IN BREAST-CANCER PATIENTS IN RELATION TO PROGNOSIS". Oncology Reports 2, no. 5 (1995): 759-761. https://doi.org/10.3892/or.2.5.759
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