INCREASED EXPRESSION AND PHOSPHORYLATION OF SH-PTP2 (SYP) IN HUMAN GASTRIC CARCINOMAS

  • Authors:
    • K KITAHARA
    • W YASUI
    • H KUNIYASU
    • H YOKOZAKI
    • S YUNOTANI
    • T HISATSUGU
    • E TAHARA
  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/or.2.5.819
  • Pages: 819-823
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Abstract

The expression of SH-PTP2 (SYP), a novel protein tyrosine phosphatase with src homology 2, was examined in human gastric carcinoma cell lines and gastric carcinoma tissues as well as corresponding non-neoplastic mucosas by Northern and Western blotting. The expression of SH-PTP2 mRNA was detected in all 8 gastric carcinoma cell lines at various levels. Most of the cell lines expressed SH-PTP2 protein of 70 kd which corresponds to tyrosine-phosphorylated form, whereas only one cell line expressed unphosphorylated form of SH-PTP2; Fourteen (66.6%) of 21 gastric carcinomas expressed SH-PTP2 mRNA at higher level than non-neoplastic mucosas. Furthermore, most of the gastric carcinomas displayed higher levels of tyrosine-phosphorylated form of SH-PTP2, while non-neoplastic mucosas tended to express unphosphorylated SH-PTP2 protein. These results suggest that the increased expression and tyrosine-phosphorylation of SH-PTP2 may participate in stomach carcinogenesis.

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September 1995
Volume 2 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
KITAHARA K, YASUI W, KUNIYASU H, YOKOZAKI H, YUNOTANI S, HISATSUGU T and TAHARA E: INCREASED EXPRESSION AND PHOSPHORYLATION OF SH-PTP2 (SYP) IN HUMAN GASTRIC CARCINOMAS. Oncol Rep 2: 819-823, 1995
APA
KITAHARA, K., YASUI, W., KUNIYASU, H., YOKOZAKI, H., YUNOTANI, S., HISATSUGU, T., & TAHARA, E. (1995). INCREASED EXPRESSION AND PHOSPHORYLATION OF SH-PTP2 (SYP) IN HUMAN GASTRIC CARCINOMAS. Oncology Reports, 2, 819-823. https://doi.org/10.3892/or.2.5.819
MLA
KITAHARA, K., YASUI, W., KUNIYASU, H., YOKOZAKI, H., YUNOTANI, S., HISATSUGU, T., TAHARA, E."INCREASED EXPRESSION AND PHOSPHORYLATION OF SH-PTP2 (SYP) IN HUMAN GASTRIC CARCINOMAS". Oncology Reports 2.5 (1995): 819-823.
Chicago
KITAHARA, K., YASUI, W., KUNIYASU, H., YOKOZAKI, H., YUNOTANI, S., HISATSUGU, T., TAHARA, E."INCREASED EXPRESSION AND PHOSPHORYLATION OF SH-PTP2 (SYP) IN HUMAN GASTRIC CARCINOMAS". Oncology Reports 2, no. 5 (1995): 819-823. https://doi.org/10.3892/or.2.5.819