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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 1995 Volume 2 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1995 Volume 2 Issue 5

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Article

SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS

  • Authors:
    • MH CHAMPEME
    • S MAZOYER
    • D STOPPALYONNET
    • I BIECHE
    • G ITHIER
    • H SOBOL
    • C NOGUES
    • R LIDEREAU

  • View Affiliations / Copyright

    Affiliations: CTR RENE HUGUENIN,ONCOGENET LAB,F-92211 ST CLOUD,FRANCE. CTR LEON BERARD,UNITE ONCOL GENET,F-69008 LYON,FRANCE. INST CURIE,UNITE GENET ONCOL,F-75231 PARIS 05,FRANCE.
  • Pages: 825-831
    |
    Published online on: September 1, 1995
       https://doi.org/10.3892/or.2.5.825
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Abstract

Frequent loss of heterozygosity (LOH) on the long arm of chromosome 17 has been described in breast tumor DNAs by a number of groups, and recent fine genetic mapping and cloning of an inherited breast-ovarian cancer susceptibility locus (BRCA1) to a small region of 17q12-q21 has focused interest on this area. The absence of sporadic mutations in the BRCA1 gene in breast tumors studied so far suggests that there may be other tumor suppressor genes in the region involved in sporadic breast cancer. We studied 28 sporadic breast cancers with 14 highly polymorphic markers on chromosome 17 (2 on 17p and 12 on 17q). Most of the 17q markers are located within the 17q12-q23 region. We confirmed that 50% of tumors have deletions of at least one locus on chromosome arm 17q, and that half the deleted cases probably correspond to monosomies 17 or 17q. The other half correspond to a partial deletion on 17q and were used to identify 2 smallest common deleted regions (SCDR1 and SCDR2) on 17q12-q23. SCDR1 comprised the THRA1 gene, but not the 2 flanking loci tested (D17S250 and D17S800); while SCDR2 was defined by loci GIP and GH. BRCA1 was deleted in half the cases but it is outside the SCDR1. Moreover, breast tumors in young women frequently showed chromosome 17 alterations.

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Copy and paste a formatted citation
Spandidos Publications style
CHAMPEME M, MAZOYER S, STOPPALYONNET D, BIECHE I, ITHIER G, SOBOL H, NOGUES C and LIDEREAU R: SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS. Oncol Rep 2: 825-831, 1995.
APA
CHAMPEME, M., MAZOYER, S., STOPPALYONNET, D., BIECHE, I., ITHIER, G., SOBOL, H. ... LIDEREAU, R. (1995). SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS. Oncology Reports, 2, 825-831. https://doi.org/10.3892/or.2.5.825
MLA
CHAMPEME, M., MAZOYER, S., STOPPALYONNET, D., BIECHE, I., ITHIER, G., SOBOL, H., NOGUES, C., LIDEREAU, R."SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS". Oncology Reports 2.5 (1995): 825-831.
Chicago
CHAMPEME, M., MAZOYER, S., STOPPALYONNET, D., BIECHE, I., ITHIER, G., SOBOL, H., NOGUES, C., LIDEREAU, R."SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS". Oncology Reports 2, no. 5 (1995): 825-831. https://doi.org/10.3892/or.2.5.825
Copy and paste a formatted citation
x
Spandidos Publications style
CHAMPEME M, MAZOYER S, STOPPALYONNET D, BIECHE I, ITHIER G, SOBOL H, NOGUES C and LIDEREAU R: SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS. Oncol Rep 2: 825-831, 1995.
APA
CHAMPEME, M., MAZOYER, S., STOPPALYONNET, D., BIECHE, I., ITHIER, G., SOBOL, H. ... LIDEREAU, R. (1995). SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS. Oncology Reports, 2, 825-831. https://doi.org/10.3892/or.2.5.825
MLA
CHAMPEME, M., MAZOYER, S., STOPPALYONNET, D., BIECHE, I., ITHIER, G., SOBOL, H., NOGUES, C., LIDEREAU, R."SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS". Oncology Reports 2.5 (1995): 825-831.
Chicago
CHAMPEME, M., MAZOYER, S., STOPPALYONNET, D., BIECHE, I., ITHIER, G., SOBOL, H., NOGUES, C., LIDEREAU, R."SUBLOCALIZATION OF SMALLEST COMMON REGIONS OF DELETION ON CHROMOSOME 17Q12-Q23 IN SPORADIC PRIMARY BREAST-TUMORS". Oncology Reports 2, no. 5 (1995): 825-831. https://doi.org/10.3892/or.2.5.825
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