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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 1995 Volume 2 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1995 Volume 2 Issue 6

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Article

ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS

  • Authors:
    • SM SWANSON
    • JM PEZZUTO

  • View Affiliations / Copyright

    Affiliations: UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY MC 781,CHICAGO,IL 60612. UNIV ILLINOIS,COLL MED,DEPT SURG ONCOL,CHICAGO,IL 60612.
  • Pages: 1011-1015
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/or.2.6.1011
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Abstract

As suggested by animal studies and human epidemiological data, retinoids possess significant cancer chemopreventive activity. Although the majority of studies in this area have focused on the ability of retinoids to prevent the promotion or progression of carcinogenesis, a significant amount of data suggest retinoids can alter initiation events. In the current report, we have evaluated the potential of retinol acetate to modulate benzo(a)pyrene metabolism in low-passage human bronchial epithelial cells in monolayer cultures, Of 16 different cell cultures, benzo(a)pyrene metabolism was increased in 14, decreased in one, and unchanged in one, when retinol acetate was added to the media, In a preliminary study with one of the cell cultures in which retinol acetate significantly enhanced benzo(a)pyrene metabolism, binding of carcinogen metabolites to;DNA was unaffected, Since retinoids are known cancer chemopreventive agents and carcinogen binding to DNA is the key event in the initiation of carcinogenesis, these results suggest that retinoids may decrease carcinogenic risk by increasing the detoxification of procarcinogens such as benzo(a)pyrene ina manner that does not yield a concomitant increase in damage to critical cellular targets such as DNA.

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Copy and paste a formatted citation
Spandidos Publications style
SWANSON S and PEZZUTO J: ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS. Oncol Rep 2: 1011-1015, 1995.
APA
SWANSON, S., & PEZZUTO, J. (1995). ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS. Oncology Reports, 2, 1011-1015. https://doi.org/10.3892/or.2.6.1011
MLA
SWANSON, S., PEZZUTO, J."ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS". Oncology Reports 2.6 (1995): 1011-1015.
Chicago
SWANSON, S., PEZZUTO, J."ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS". Oncology Reports 2, no. 6 (1995): 1011-1015. https://doi.org/10.3892/or.2.6.1011
Copy and paste a formatted citation
x
Spandidos Publications style
SWANSON S and PEZZUTO J: ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS. Oncol Rep 2: 1011-1015, 1995.
APA
SWANSON, S., & PEZZUTO, J. (1995). ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS. Oncology Reports, 2, 1011-1015. https://doi.org/10.3892/or.2.6.1011
MLA
SWANSON, S., PEZZUTO, J."ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS". Oncology Reports 2.6 (1995): 1011-1015.
Chicago
SWANSON, S., PEZZUTO, J."ENHANCEMENT OF BENZO(A)PYRENE METABOLISM MEDIATED BY RETINOL ACETATE IN CULTURED HUMAN BRONCHIAL EPITHELIAL-CELLS". Oncology Reports 2, no. 6 (1995): 1011-1015. https://doi.org/10.3892/or.2.6.1011
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