EXPRESSION OF MESSENGER-RNA CD44 SPLICE VARIANTS IN PRIMARY COLON-CANCER AND LIVER METASTASES
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- Published online on: November 1, 1995 https://doi.org/10.3892/or.2.6.1103
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CD44 splice variants have been implicated in metastasis. We studied CD44 variants in 39 patients with colonic neoplasia and 8 without malignant disease using RT-PCR. CD44 splice variants were detected in most liver metastases and primary tumours and expression was unrelated to lymph node involvement. Non-neoplastic tissue was negative for variant expression. The finding that virtually all primary colorectal tumours expressed the variants studied, suggests that this early expression of polymorphism is not sufficient to confer metastasis in colorectal cancer.