search button

CISPLATIN, 5-FLUOROURACIL, AND LEUCOVORIN IN THE THERAPY OF ADENOCARCINOMAS OF THE PANCREAS

  • Authors:
    • DV JONES
    • SM SUGARMAN
    • AB MARKOWITZ
    • B LEVIN
    • JL ABBRUZZESE
    • DB EVANS
    • C CHARNSANGAVEJ
    • R SMITH
    • YZ PATT

  • View Affiliations

  • Published online on: November 1, 1995     https://doi.org/10.3892/or.2.6.1121
  • Pages: 1121-1123
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pancreatic cancer is resistant to most chemotherapeutic regimens. Based upon evidence of synergy between 5-fluorouracil (5-FU) and cisplatin (CDDP), and of enhanced 5-FU activity in the presence of leucovorin in other neoplasms, a phase II study of CDDP, 5-FU, and leucovorin was conducted to determine the efficacy of this regimen in patients with unresectable adenocarcinomas of the pancreas. Nineteen patients were enrolled, and all were evaluable for toxicity and response. One complete and two partial responses were observed (15.8%). Adverse effects were reversible and tolerable. This regimen has limited activity against pancreatic cancer, and cannot be recommended as standard therapy in this disease.

Related Articles

Journal Cover

November 1995
Volume 2 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
JONES D, SUGARMAN S, MARKOWITZ A, LEVIN B, ABBRUZZESE J, EVANS D, CHARNSANGAVEJ C, SMITH R and PATT Y: CISPLATIN, 5-FLUOROURACIL, AND LEUCOVORIN IN THE THERAPY OF ADENOCARCINOMAS OF THE PANCREAS. Oncol Rep 2: 1121-1123, 1995
APA
JONES, D., SUGARMAN, S., MARKOWITZ, A., LEVIN, B., ABBRUZZESE, J., EVANS, D. ... PATT, Y. (1995). CISPLATIN, 5-FLUOROURACIL, AND LEUCOVORIN IN THE THERAPY OF ADENOCARCINOMAS OF THE PANCREAS. Oncology Reports, 2, 1121-1123. https://doi.org/10.3892/or.2.6.1121
MLA
JONES, D., SUGARMAN, S., MARKOWITZ, A., LEVIN, B., ABBRUZZESE, J., EVANS, D., CHARNSANGAVEJ, C., SMITH, R., PATT, Y."CISPLATIN, 5-FLUOROURACIL, AND LEUCOVORIN IN THE THERAPY OF ADENOCARCINOMAS OF THE PANCREAS". Oncology Reports 2.6 (1995): 1121-1123.
Chicago
JONES, D., SUGARMAN, S., MARKOWITZ, A., LEVIN, B., ABBRUZZESE, J., EVANS, D., CHARNSANGAVEJ, C., SMITH, R., PATT, Y."CISPLATIN, 5-FLUOROURACIL, AND LEUCOVORIN IN THE THERAPY OF ADENOCARCINOMAS OF THE PANCREAS". Oncology Reports 2, no. 6 (1995): 1121-1123. https://doi.org/10.3892/or.2.6.1121