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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2011 Volume 25 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53

  • Authors:
    • Ya-Fei Zhang
    • Xiao-Hua Li
    • Yong-Quan Shi
    • Yu-Yun Wu
    • Ning Li
    • Qiang He
    • Qing Ji
    • Rong-Quan Wang
    • Shi-Ming Yang
    • Dian-Chun Fang

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 1091-1098
    |
    Published online on: January 14, 2011
       https://doi.org/10.3892/or.2011.1148
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Abstract

Recent investigations discovered that CIAPIN1 might be another drug resistance-associated molecule in cancer cells. However, the underlying mechanisms of CIAPIN1-related multidrug resistance (MDR) remain elusive. In the present study, we investigated the role and possible mechanisms of CIAPIN1 in MDR of human colon carcinoma LoVo/Adr cells which express the wild-type p53 gene. By using small interference RNA and gene transfection techniques, we found that knockdown of CIAPIN1 expression re-sensitized LoVo/Adr cells to anti-cancer drugs and up-regulation of CIAPIN1 in sensitive LoVo cells resulted in a distinct MDR phenotype. We further revealed that CIAPIN1 conferred the MDR phenotype in LoVo/Adr cells through up-regulating expression of MDR-1 (P-gp) and Bcl-xL. Finally, by analyzing the effect of inactivation of wild-type p53 on CIAPIN1-induced up-regulation of P-gp and Bcl-xL, we determined that CIAPIN1 could exhibit its MDR-related function independently of the p53 signaling pathway. Overall, the results presented here further suggest that over-expression of CIAPIN1 is an important mechanism of drug resistance in human cancers, even if not the sole one.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Li X, Shi Y, Wu Y, Li N, He Q, Ji Q, Wang R, Yang S, Fang D, Fang D, et al: CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53. Oncol Rep 25: 1091-1098, 2011.
APA
Zhang, Y., Li, X., Shi, Y., Wu, Y., Li, N., He, Q. ... Fang, D. (2011). CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53. Oncology Reports, 25, 1091-1098. https://doi.org/10.3892/or.2011.1148
MLA
Zhang, Y., Li, X., Shi, Y., Wu, Y., Li, N., He, Q., Ji, Q., Wang, R., Yang, S., Fang, D."CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53". Oncology Reports 25.4 (2011): 1091-1098.
Chicago
Zhang, Y., Li, X., Shi, Y., Wu, Y., Li, N., He, Q., Ji, Q., Wang, R., Yang, S., Fang, D."CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53". Oncology Reports 25, no. 4 (2011): 1091-1098. https://doi.org/10.3892/or.2011.1148
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Li X, Shi Y, Wu Y, Li N, He Q, Ji Q, Wang R, Yang S, Fang D, Fang D, et al: CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53. Oncol Rep 25: 1091-1098, 2011.
APA
Zhang, Y., Li, X., Shi, Y., Wu, Y., Li, N., He, Q. ... Fang, D. (2011). CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53. Oncology Reports, 25, 1091-1098. https://doi.org/10.3892/or.2011.1148
MLA
Zhang, Y., Li, X., Shi, Y., Wu, Y., Li, N., He, Q., Ji, Q., Wang, R., Yang, S., Fang, D."CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53". Oncology Reports 25.4 (2011): 1091-1098.
Chicago
Zhang, Y., Li, X., Shi, Y., Wu, Y., Li, N., He, Q., Ji, Q., Wang, R., Yang, S., Fang, D."CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53". Oncology Reports 25, no. 4 (2011): 1091-1098. https://doi.org/10.3892/or.2011.1148
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