Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer

  • Authors:
    • Zhimou Xue
    • Ping Hu Sun
    • Li Ming Zhu
    • Shi Hu Jiang
    • Min Min Qiao
    • Alfred L. Chi
    • Shui Ping Tu
  • View Affiliations

  • Published online on: January 28, 2011     https://doi.org/10.3892/or.2011.1166
  • Pages: 1039-1046
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Abstract

Colon cancer is one of the most common cancers. Survivin is overexpressed in human colon cancer and correlate with chemoresistance, angiogenesis and poor prognosis. Oxaliplatin, a platinum derivative cancer drug, has been used for treating human colorectal cancers. In the present study, we investigated the effect of the adeno-associated virus (AAV)-mediated survivin mutant Thr34Ala [rAAV-Sur-Mut(T34A)] on colon cancer growth. Infection with rAAV-Sur-Mut(T34A) inhibited cell proliferation, induced apoptosis and mitotic catastrophe, and sensitized colon cancer cells to chemotherapeutic drugs in vitro. Treatment with rAAV-Sur-Mut(T34A) significantly induced apoptosis, reduced angiogenesis and inhibited colon cancer growth in vivo. More importantly, rAAV-Sur-Mut(T34A) treatment strongly enhanced the anti-tumor activity of oxaliplatin and prolonged animal survival. Thus, the use of rAAV-Sur-Mut(T34A) in combination with chemotherapy may be a promising strategy for colon cancer therapy.

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April 2011
Volume 25 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xue Z, Sun PH, Zhu LM, Jiang SH, Qiao MM, Chi AL and Tu SP: Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer. Oncol Rep 25: 1039-1046, 2011.
APA
Xue, Z., Sun, P.H., Zhu, L.M., Jiang, S.H., Qiao, M.M., Chi, A.L., & Tu, S.P. (2011). Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer. Oncology Reports, 25, 1039-1046. https://doi.org/10.3892/or.2011.1166
MLA
Xue, Z., Sun, P. H., Zhu, L. M., Jiang, S. H., Qiao, M. M., Chi, A. L., Tu, S. P."Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer". Oncology Reports 25.4 (2011): 1039-1046.
Chicago
Xue, Z., Sun, P. H., Zhu, L. M., Jiang, S. H., Qiao, M. M., Chi, A. L., Tu, S. P."Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer". Oncology Reports 25, no. 4 (2011): 1039-1046. https://doi.org/10.3892/or.2011.1166