The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo

  • Authors:
    • Juyeon Jung
    • Yeon Sung Son
    • Hongryeol Park
    • Seong Kook Jeon
    • Jung Whoi Lee
    • Song-Yi Choi
    • Jin-Man Kim
    • Young-Guen Kwon
    • Hyo Jeong Hong
    • Jeong-Ki Min
  • View Affiliations

  • Published online on: February 11, 2011     https://doi.org/10.3892/or.2011.1181
  • Pages: 945-952
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Abstract

Recent studies have demonstrated that the cell adhesion molecule, L1, is expressed in several malignant tumor types and its expression correlates with tumor progression and metastasis. However, the role of L1 in gallbladder carcinoma (GBC) remains unclear. Here, we demonstrate that L1 is expressed in GBC cells and plays an important role in the growth, motility, invasiveness, and adhesiveness of GBC cells. Specific depletion or overexpression of L1 in the GBC cell lines JCRB1033 and SNU-308, respectively, was achieved by lentivirus-mediated transduction and expression of an L1 mRNA-specific short hairpin RNA or full-length human L1. Stable depletion of L1 led to a significant decrease in GBC cell proliferation, migration and invasion, as well as decreased intracellular signaling through AKT and FAK. Overexpression of L1 in GBC cells enhanced these cellular activities. In a GBC xenograft nude mouse model, suppression of L1 markedly reduced tumor growth and increased the survival of tumor-bearing mice whereas L1 overexpression stimulated tumorigenicity. Taken together, these results suggest that L1 plays a crucial role in GBC progression and may be a novel therapeutic target in GBC treatment.

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April 2011
Volume 25 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jung J, Son YS, Park H, Jeon SK, Lee JW, Choi S, Kim J, Kwon Y, Hong HJ, Min J, Min J, et al: The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo. Oncol Rep 25: 945-952, 2011
APA
Jung, J., Son, Y.S., Park, H., Jeon, S.K., Lee, J.W., Choi, S. ... Min, J. (2011). The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo. Oncology Reports, 25, 945-952. https://doi.org/10.3892/or.2011.1181
MLA
Jung, J., Son, Y. S., Park, H., Jeon, S. K., Lee, J. W., Choi, S., Kim, J., Kwon, Y., Hong, H. J., Min, J."The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo". Oncology Reports 25.4 (2011): 945-952.
Chicago
Jung, J., Son, Y. S., Park, H., Jeon, S. K., Lee, J. W., Choi, S., Kim, J., Kwon, Y., Hong, H. J., Min, J."The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo". Oncology Reports 25, no. 4 (2011): 945-952. https://doi.org/10.3892/or.2011.1181