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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2011 Volume 25 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review

Methylation in oral cancer and pre-cancerous lesions (Review)

  • Authors:
    • R. Díez-Pérez
    • J. Campo-Trapero
    • J. Cano-Sánchez
    • M. López-Durán
    • M. A. Gonzalez-Moles
    • J. Bascones-Ilundain
    • A. Bascones-Martinez

  • View Affiliations / Copyright

    Affiliations: School of Dentistry, UCM, Madrid, Spain, Department of Stomatology, Plaza de Ramón y Cajal 3, Ciudad Universitaria, 28040 Madrid, Spain
  • Pages: 1203-1209
    |
    Published online on: March 4, 2011
       https://doi.org/10.3892/or.2011.1205
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Abstract

There is considerable interest in the analysis of epigenetic alterations in cancer, including oral cancer and pre-cancerous lesions. These processes affect or inactivate the functions of genes without altering their structure or sequence. One example is the methylation of the promoter region of some genes involved in cell cycle control. Knowledge of methylation patterns is very important for understanding the expression of genes in normal and pathological situations. This review provides an update on research into this issue in oral cancer and pre-cancerous lesions. A greater understanding of this epigenetic alteration could not only assist the diagnosis and prognosis of oral cancer but could also open up novel therapeutic approaches. The presence of methylation in specific tumour suppressor genes could modify their function and alter cell cycle control, so the patients could have an increased risk of developing cancer and also a higher degree of malignancy. The most frequently and extensively studied methylated genes in oral premalignant lesions are p16, MGMT, RARβ2, E-cadherin and DAP-kinase.

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Copy and paste a formatted citation
Spandidos Publications style
Díez-Pérez R, Campo-Trapero J, Cano-Sánchez J, López-Durán M, Gonzalez-Moles MA, Bascones-Ilundain J and Bascones-Martinez A: Methylation in oral cancer and pre-cancerous lesions (Review). Oncol Rep 25: 1203-1209, 2011.
APA
Díez-Pérez, R., Campo-Trapero, J., Cano-Sánchez, J., López-Durán, M., Gonzalez-Moles, M.A., Bascones-Ilundain, J., & Bascones-Martinez, A. (2011). Methylation in oral cancer and pre-cancerous lesions (Review). Oncology Reports, 25, 1203-1209. https://doi.org/10.3892/or.2011.1205
MLA
Díez-Pérez, R., Campo-Trapero, J., Cano-Sánchez, J., López-Durán, M., Gonzalez-Moles, M. A., Bascones-Ilundain, J., Bascones-Martinez, A."Methylation in oral cancer and pre-cancerous lesions (Review)". Oncology Reports 25.5 (2011): 1203-1209.
Chicago
Díez-Pérez, R., Campo-Trapero, J., Cano-Sánchez, J., López-Durán, M., Gonzalez-Moles, M. A., Bascones-Ilundain, J., Bascones-Martinez, A."Methylation in oral cancer and pre-cancerous lesions (Review)". Oncology Reports 25, no. 5 (2011): 1203-1209. https://doi.org/10.3892/or.2011.1205
Copy and paste a formatted citation
x
Spandidos Publications style
Díez-Pérez R, Campo-Trapero J, Cano-Sánchez J, López-Durán M, Gonzalez-Moles MA, Bascones-Ilundain J and Bascones-Martinez A: Methylation in oral cancer and pre-cancerous lesions (Review). Oncol Rep 25: 1203-1209, 2011.
APA
Díez-Pérez, R., Campo-Trapero, J., Cano-Sánchez, J., López-Durán, M., Gonzalez-Moles, M.A., Bascones-Ilundain, J., & Bascones-Martinez, A. (2011). Methylation in oral cancer and pre-cancerous lesions (Review). Oncology Reports, 25, 1203-1209. https://doi.org/10.3892/or.2011.1205
MLA
Díez-Pérez, R., Campo-Trapero, J., Cano-Sánchez, J., López-Durán, M., Gonzalez-Moles, M. A., Bascones-Ilundain, J., Bascones-Martinez, A."Methylation in oral cancer and pre-cancerous lesions (Review)". Oncology Reports 25.5 (2011): 1203-1209.
Chicago
Díez-Pérez, R., Campo-Trapero, J., Cano-Sánchez, J., López-Durán, M., Gonzalez-Moles, M. A., Bascones-Ilundain, J., Bascones-Martinez, A."Methylation in oral cancer and pre-cancerous lesions (Review)". Oncology Reports 25, no. 5 (2011): 1203-1209. https://doi.org/10.3892/or.2011.1205
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