Aurora-A as an independent molecular prognostic marker in gastric cancer

  • Authors:
    • Jing Wang
    • Sheng Yang
    • Haizeng Zhang
    • Yan Song
    • Xun Zhang
    • Haili Qian
    • Xiaohong Han
    • Yuankai Shi
  • View Affiliations

  • Published online on: April 6, 2011     https://doi.org/10.3892/or.2011.1250
  • Pages: 23-32
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Abstract

Aurora-A, encoding serine/threonine kinases with a key role in mitosis has been demonstrated to be involved in tumor progression. Hematogenous and lymphatic metastasis are also involved in cancer progression. Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) have been implicated in tumor-related angiogenesis and lymphagenesis. The purpose of this study was to analyze the expression and prognostic significance of Aurora-A, VEGFs and VEGFRs in gastric cancer. The expression profiles of Aurora-A, VEGF-A and VEGF-D in gastric cancer cell lines were detected employing real-time reverse transcription polymerase chain reaction and Western blot analysis. The expression levels of Aurora-A, VEGF-A/VEGFR-2, VEGF-D/VEGFR-3 and clinicopathological characteristics were analyzed in 89 gastric cancer patients treated with curative surgery. Univariate analysis demonstrated that histological grade (P=0.052), TNM stage (P<0.001), lymphovascular involvement (P<0.001), Aurora-A (P<0.001) and VEGF-D (P=0.048) were prognostic factors. The presence of Aurora-A was correlated with tumor progression (P=0.053) and shorter survival (P=0.001). Cox multivariate regression analysis demonstrated that Aurora-A positive expression, stage III-IV and lymphovascular involvement were independent unfavorable prognostic factors in gastric cancer. Aurora-A positive expression was predictive for worse outcome in patients without lymph node metastasis (P<0.05) and in patients with stage III-IV (P<0.001). Aurora-A could serve as an independent prognostic marker in gastric cancer and could identify patients with worse outcome even in a relatively early and local disease, thus offering valuable information for administering individualized treatment and/or surveillance for these patients.

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July 2011
Volume 26 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Yang S, Zhang H, Song Y, Zhang X, Qian H, Han X and Shi Y: Aurora-A as an independent molecular prognostic marker in gastric cancer. Oncol Rep 26: 23-32, 2011
APA
Wang, J., Yang, S., Zhang, H., Song, Y., Zhang, X., Qian, H. ... Shi, Y. (2011). Aurora-A as an independent molecular prognostic marker in gastric cancer. Oncology Reports, 26, 23-32. https://doi.org/10.3892/or.2011.1250
MLA
Wang, J., Yang, S., Zhang, H., Song, Y., Zhang, X., Qian, H., Han, X., Shi, Y."Aurora-A as an independent molecular prognostic marker in gastric cancer". Oncology Reports 26.1 (2011): 23-32.
Chicago
Wang, J., Yang, S., Zhang, H., Song, Y., Zhang, X., Qian, H., Han, X., Shi, Y."Aurora-A as an independent molecular prognostic marker in gastric cancer". Oncology Reports 26, no. 1 (2011): 23-32. https://doi.org/10.3892/or.2011.1250