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July 2011 Volume 26 Issue 1

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes

  • Authors:
    • Vincenzo Falbo
    • Giovanna Floridia
    • Federica Censi
    • Manuela Marra
    • Maria P. Foschini
    • Domenica Taruscio

  • View Affiliations / Copyright

    Affiliations: National Centre for Rare Diseases, Istituto Superiore di Sanità, Via Regina Elena 299, 00161 Rome, Italy
  • Pages: 3-11
    |
    Published online on: April 14, 2011
       https://doi.org/10.3892/or.2011.1263
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Abstract

Salivary gland tumours are rare tumours characterized by histopathologic complexity and a wide variety of morphologic features. Studies on genetic changes in different histological subtypes of salivary gland tumours are important to better understand molecular pathogenetic mechanisms and to identify diagnostic and prognostic markers. Data are even more scanty dealing with unusual subtypes of these tumours. The aim of the present study was to analyse two high grade transformation adenoid cystic carcinomas (hgACC) and one hybrid tumour in order to identify, by mutational and microsatellite analysis, genetic alterations in TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes. The two hgACCs showed snps missense in RAS genes and alterations with allelic instability in CDKN2A/ARF; moreover, a double mutation in TP53 was detected in one case. The hybrid tumour showed alterations in CDKN2A/ARF gene and snps missense in NRAS genes. Our data suggest that CDKN2A/ARF pathway might be involved in pathogenesis of the salivary gland tumours analysed. Further molecular analyses of these very rare tumours are necessary to better understand the role of other genetic alterations detected in our study.

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Copy and paste a formatted citation
Spandidos Publications style
Falbo V, Floridia G, Censi F, Marra M, Foschini MP and Taruscio D: Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes. Oncol Rep 26: 3-11, 2011.
APA
Falbo, V., Floridia, G., Censi, F., Marra, M., Foschini, M.P., & Taruscio, D. (2011). Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes. Oncology Reports, 26, 3-11. https://doi.org/10.3892/or.2011.1263
MLA
Falbo, V., Floridia, G., Censi, F., Marra, M., Foschini, M. P., Taruscio, D."Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes". Oncology Reports 26.1 (2011): 3-11.
Chicago
Falbo, V., Floridia, G., Censi, F., Marra, M., Foschini, M. P., Taruscio, D."Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes". Oncology Reports 26, no. 1 (2011): 3-11. https://doi.org/10.3892/or.2011.1263
Copy and paste a formatted citation
x
Spandidos Publications style
Falbo V, Floridia G, Censi F, Marra M, Foschini MP and Taruscio D: Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes. Oncol Rep 26: 3-11, 2011.
APA
Falbo, V., Floridia, G., Censi, F., Marra, M., Foschini, M.P., & Taruscio, D. (2011). Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes. Oncology Reports, 26, 3-11. https://doi.org/10.3892/or.2011.1263
MLA
Falbo, V., Floridia, G., Censi, F., Marra, M., Foschini, M. P., Taruscio, D."Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes". Oncology Reports 26.1 (2011): 3-11.
Chicago
Falbo, V., Floridia, G., Censi, F., Marra, M., Foschini, M. P., Taruscio, D."Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes". Oncology Reports 26, no. 1 (2011): 3-11. https://doi.org/10.3892/or.2011.1263
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