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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2011 Volume 26 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2011 Volume 26 Issue 1

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Article

Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9

  • Authors:
    • Zhu Yuan
    • Andrew J. Sanders
    • Lin Ye
    • Yu Wang
    • Wen G. Jiang

  • View Affiliations / Copyright

    Affiliations: Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
  • Pages: 237-245
    |
    Published online on: April 18, 2011
       https://doi.org/10.3892/or.2011.1271
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Abstract

HuR, a ubiquitously expressed member of the Hu family, selectively binds and stabilizes ARE-containing mRNAs encoding proto-oncogenes, cell cycle regulators, cytokines and growth factors. The role of HuR and its cellular function in breast cancer remains unclear. This study aimed to provide new insights into the implication of HuR in breast cancer. We show that MCF7 and MDA-MB-231 breast cancer cells stably transfected with a hammerhead ribozyme transgene specifically targeted to HuR (MCF7HuRKO and MDA-MB-231HuRKO) have reduced HuR expression both at mRNA and protein levels. This study reveals that HuR knockdown dramatically reduced cell growth in MCF7 cells (P<0.001) and invasive properties in MDA-MB-231 cells (P<0.001). Furthermore, we report that the decreased cell growth rate in MCF7 cells is seen together with a reduction in cyclin D1 transcript and protein levels and that the change in invasiveness in MDA-MB-231 cells seems to be linked with decreased MMP-9 levels. Our study shows that targeting HuR can influence breast cancer cell growth and invasion and suggests a role for HuR in vitro in enhancing breast cancer cell growth and invasion. These changes may be facilitated through changes in the levels of cyclin D1 and MMP-9.

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Copy and paste a formatted citation
Spandidos Publications style
Yuan Z, Sanders AJ, Ye L, Wang Y and Jiang WG: Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9. Oncol Rep 26: 237-245, 2011.
APA
Yuan, Z., Sanders, A.J., Ye, L., Wang, Y., & Jiang, W.G. (2011). Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9. Oncology Reports, 26, 237-245. https://doi.org/10.3892/or.2011.1271
MLA
Yuan, Z., Sanders, A. J., Ye, L., Wang, Y., Jiang, W. G."Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9". Oncology Reports 26.1 (2011): 237-245.
Chicago
Yuan, Z., Sanders, A. J., Ye, L., Wang, Y., Jiang, W. G."Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9". Oncology Reports 26, no. 1 (2011): 237-245. https://doi.org/10.3892/or.2011.1271
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan Z, Sanders AJ, Ye L, Wang Y and Jiang WG: Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9. Oncol Rep 26: 237-245, 2011.
APA
Yuan, Z., Sanders, A.J., Ye, L., Wang, Y., & Jiang, W.G. (2011). Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9. Oncology Reports, 26, 237-245. https://doi.org/10.3892/or.2011.1271
MLA
Yuan, Z., Sanders, A. J., Ye, L., Wang, Y., Jiang, W. G."Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9". Oncology Reports 26.1 (2011): 237-245.
Chicago
Yuan, Z., Sanders, A. J., Ye, L., Wang, Y., Jiang, W. G."Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9". Oncology Reports 26, no. 1 (2011): 237-245. https://doi.org/10.3892/or.2011.1271
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