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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2011 Volume 26 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2011 Volume 26 Issue 2

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Article

Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells

  • Authors:
    • Zhenying Guo
    • Yuanzheng He
    • Shuangshuang Wang
    • Aixia Zhang
    • Ping Zhao
    • Chongfeng Gao
    • Brian Cao

  • View Affiliations / Copyright

    Affiliations: Nanjing Medical University, Department of Pathology, Nanjing 210029, P.R. China, Van Andel Institute, 333 Bostwick Ave. NE, Grand Rapids, MI 49503, USA
  • Pages: 511-517
    |
    Published online on: May 4, 2011
       https://doi.org/10.3892/or.2011.1295
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Abstract

Hepatoma-derived growth factor (HDGF) has been implicated in the growth and metastasis of various types of human cancer, but the role of HDGF expression in prostate cancer or breast cancer has not been documented. To assess the role of HDGF in the proliferation, migration and invasion by prostate and breast cancer cells, HDGF expression in DU145 and MCF7 cells was knocked down using siRNA, and the effect of such knockdown was assessed by MTS and [3H]-thymidine incorporation Transwell assays. Moreover, we identified differentially expressed genes that might mediate the HDGF-induced cellular effects. Our results demonstrate that down-regulation of HDGF expression significantly reduces the proliferation of both DU145 and MCF7 cells. However, down-regulation of HDGF expression in DU145 inhibited cell migration and invasion, but in MCF7 cells it stimulated cell migration and invasion. This differential effect might result from the differential induction of PIK3R1 or SERPINE1 in the two cell lines upon HDGF-siRNA treatment. In conclusion, HDGF may participate in the pathogenesis of prostate and breast cancer by promoting cell growth and it may be a therapeutic target for these cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Guo Z, He Y, Wang S, Zhang A, Zhao P, Gao C and Cao B: Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells. Oncol Rep 26: 511-517, 2011.
APA
Guo, Z., He, Y., Wang, S., Zhang, A., Zhao, P., Gao, C., & Cao, B. (2011). Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells. Oncology Reports, 26, 511-517. https://doi.org/10.3892/or.2011.1295
MLA
Guo, Z., He, Y., Wang, S., Zhang, A., Zhao, P., Gao, C., Cao, B."Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells". Oncology Reports 26.2 (2011): 511-517.
Chicago
Guo, Z., He, Y., Wang, S., Zhang, A., Zhao, P., Gao, C., Cao, B."Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells". Oncology Reports 26, no. 2 (2011): 511-517. https://doi.org/10.3892/or.2011.1295
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Z, He Y, Wang S, Zhang A, Zhao P, Gao C and Cao B: Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells. Oncol Rep 26: 511-517, 2011.
APA
Guo, Z., He, Y., Wang, S., Zhang, A., Zhao, P., Gao, C., & Cao, B. (2011). Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells. Oncology Reports, 26, 511-517. https://doi.org/10.3892/or.2011.1295
MLA
Guo, Z., He, Y., Wang, S., Zhang, A., Zhao, P., Gao, C., Cao, B."Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells". Oncology Reports 26.2 (2011): 511-517.
Chicago
Guo, Z., He, Y., Wang, S., Zhang, A., Zhao, P., Gao, C., Cao, B."Various effects of hepatoma-derived growth factor on cell growth, migration and invasion of breast cancer and prostate cancer cells". Oncology Reports 26, no. 2 (2011): 511-517. https://doi.org/10.3892/or.2011.1295
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