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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2011 Volume 26 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1

  • Authors:
    • Fan Li
    • Zhang-Qun Ye
    • Dong-Sheng Guo
    • Wei-Min Yang

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 439-446
    |
    Published online on: May 10, 2011
       https://doi.org/10.3892/or.2011.1304
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Abstract

Previous in vitro studies demonstrated that leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1), a negative regulator of EGFR, is a novel agent for suppressing bladder cancer. However, the role that LRIG1 plays in bladder cancer growth in vivo has not been elucidated in animal or clinical studies. Thus, to evaluate the suppressive effects of LRIG1 on human invasive bladder cancer in vivo, we transferred LRIG1 into athymic mice bearing T24 invasive bladder cancer xenografts mediated by an adenoviral vector. Correlations between LRIG1 expression and tumorigenicity, EGFR expression, xenograft proliferation and angiogenesis were assessed, respectively. The results indicated that tumor volume growth was retarded via Ad-LRIG1 intratumoral injection. In addition LRIG1 upregulation was well correlated with a reduction in EGFR expression and the proliferation rate of xenografts. Furthermore, microvessel densities were reduced and correlated with Ad-LRIG1 administration. No significant macroscopic and microscopic pathological abnormality was observed in the liver, kidney and lungs of Ad-LRIG1-administered mice. This new insight provides evidence that downregulation of EGFR expression by LRIG1 may comprise a potential novel and safe therapeutic approach for improving the prognosis of invasive bladder cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Li F, Ye Z, Guo D and Yang W: Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1. Oncol Rep 26: 439-446, 2011.
APA
Li, F., Ye, Z., Guo, D., & Yang, W. (2011). Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1. Oncology Reports, 26, 439-446. https://doi.org/10.3892/or.2011.1304
MLA
Li, F., Ye, Z., Guo, D., Yang, W."Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1". Oncology Reports 26.2 (2011): 439-446.
Chicago
Li, F., Ye, Z., Guo, D., Yang, W."Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1". Oncology Reports 26, no. 2 (2011): 439-446. https://doi.org/10.3892/or.2011.1304
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, Ye Z, Guo D and Yang W: Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1. Oncol Rep 26: 439-446, 2011.
APA
Li, F., Ye, Z., Guo, D., & Yang, W. (2011). Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1. Oncology Reports, 26, 439-446. https://doi.org/10.3892/or.2011.1304
MLA
Li, F., Ye, Z., Guo, D., Yang, W."Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1". Oncology Reports 26.2 (2011): 439-446.
Chicago
Li, F., Ye, Z., Guo, D., Yang, W."Suppression of bladder cancer cell tumorigenicity in an athymic mouse model by adenoviral vector-mediated transfer of LRIG1". Oncology Reports 26, no. 2 (2011): 439-446. https://doi.org/10.3892/or.2011.1304
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