CD44 as a stem cell marker in head and neck squamous cell carcinoma

  • Authors:
    • Anne Faber
    • Christine Barth
    • Karl Hörmann
    • Stefan Kassner
    • Johannes David Schultz
    • Ulrich Sommer
    • Jens Stern-Straeter
    • Carsten Thorn
    • Ulrich Reinhart Goessler
  • View Affiliations

  • Published online on: May 26, 2011     https://doi.org/10.3892/or.2011.1322
  • Pages: 321-326
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Abstract

In the recent past, evidence is increasing indicating the existence of a subpopulation of resistant tumor cells in head and neck squamous cell carcinoma (HNSCC) that cannot be eradicated by established antineoplastic treatments. These cancer stem cells (CSCs) have features of somatic stem cells such as selfrenewal, proliferation and differentiation. CD44+ cells in tumors of the head and neck are referred to as CSCs of HNSCC. Expression profiling of CD44 in 29 HNSCC tumors was performed by fluorescence microscopy. ELISA analysis was performed to detect concentration of soluble CD44 in the peripheral blood of 29 HNSCC patients and 11 healthy controls. Expression of CD44 was determined in all HNSCC tissue samples (n=29). In all samples a surface staining pattern was found. The concentration of CD44 in the peripheral blood of HNSCC patients was significantly higher compared to a healthy control group (mHNSCC=13.5±0.5 ng/ ml; mCont=9.3±0.6 ng/ml; P=0.6x10-12). The role of CD44 as a marker for CSCs in HNSCC remains to be ascertained. Further experiments might reveal its role as a diagnostic and prognostic factor, and possibly as a therapeutic target.

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August 2011
Volume 26 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Faber A, Barth C, Hörmann K, Kassner S, Schultz JD, Sommer U, Stern-Straeter J, Thorn C and Goessler UR: CD44 as a stem cell marker in head and neck squamous cell carcinoma. Oncol Rep 26: 321-326, 2011.
APA
Faber, A., Barth, C., Hörmann, K., Kassner, S., Schultz, J.D., Sommer, U. ... Goessler, U.R. (2011). CD44 as a stem cell marker in head and neck squamous cell carcinoma. Oncology Reports, 26, 321-326. https://doi.org/10.3892/or.2011.1322
MLA
Faber, A., Barth, C., Hörmann, K., Kassner, S., Schultz, J. D., Sommer, U., Stern-Straeter, J., Thorn, C., Goessler, U. R."CD44 as a stem cell marker in head and neck squamous cell carcinoma". Oncology Reports 26.2 (2011): 321-326.
Chicago
Faber, A., Barth, C., Hörmann, K., Kassner, S., Schultz, J. D., Sommer, U., Stern-Straeter, J., Thorn, C., Goessler, U. R."CD44 as a stem cell marker in head and neck squamous cell carcinoma". Oncology Reports 26, no. 2 (2011): 321-326. https://doi.org/10.3892/or.2011.1322