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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2011 Volume 26 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin

  • Authors:
    • Yukiko Nishikawa
    • Tatsuhiko Miyazaki
    • Koh-Ichi Nakashiro
    • Hidehisa Yamagata
    • Mayumi Isokane
    • Hiroyuki Goda
    • Hiroshi Tanaka
    • Ryota Oka
    • Hiroyuki Hamakawa

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan, Department of Pathogenomics, Ehime University Graduate School of Medicine, 454 Shitsukawa, To-on, Ehime, 791-0295, Japan
  • Pages: 587-592
    |
    Published online on: May 26, 2011
       https://doi.org/10.3892/or.2011.1324
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Abstract

FAT1 [Homo sapiens FAT tumor suppressor homolog 1 (Drosophila)] is an intrinsic membrane protein classified as a member of the cadherin superfamily. The FAT1 gene is a tumor suppressor in humans as well as being the pivotal gene for cell morphogenesis and migration. Deletion of this gene could play a role in the characteristics of oral squamous cell carcinomas (OSCCs), involving cell adhesion, migration and/or invasion. This study investigated the mechanisms by which FAT1 is involved in the biological behavior of OSCCs. First, a rat monoclonal antibody was developed against a FAT1 intra-cellular domain epitope, and used for an immunohistochemical study of FAT1 in clinically obtained OSCC samples. FAT1 was localized at lamellipodial edges or cell-cell boundaries in normal cells and well differentiated OSCCs, but showed a diffuse cytoplasmic and nuclear distribution in moderately-poorly differentiated OSCCs. FAT1-siRNA was transfected into OSCCs resulting in a drastic inhibition of cell migration and invasion based on the suppression of FAT1 expression and disorganized localization of β-catenin which is associated with cell polarity and migration. These results suggested that FAT1 may be involved in the migration and invasion mechanisms of OSCCs and, therefore, it could be an important target for the development of new therapeutic strategies.

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Copy and paste a formatted citation
Spandidos Publications style
Nishikawa Y, Miyazaki T, Nakashiro K, Yamagata H, Isokane M, Goda H, Tanaka H, Oka R and Hamakawa H: Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin. Oncol Rep 26: 587-592, 2011.
APA
Nishikawa, Y., Miyazaki, T., Nakashiro, K., Yamagata, H., Isokane, M., Goda, H. ... Hamakawa, H. (2011). Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin. Oncology Reports, 26, 587-592. https://doi.org/10.3892/or.2011.1324
MLA
Nishikawa, Y., Miyazaki, T., Nakashiro, K., Yamagata, H., Isokane, M., Goda, H., Tanaka, H., Oka, R., Hamakawa, H."Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin". Oncology Reports 26.3 (2011): 587-592.
Chicago
Nishikawa, Y., Miyazaki, T., Nakashiro, K., Yamagata, H., Isokane, M., Goda, H., Tanaka, H., Oka, R., Hamakawa, H."Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin". Oncology Reports 26, no. 3 (2011): 587-592. https://doi.org/10.3892/or.2011.1324
Copy and paste a formatted citation
x
Spandidos Publications style
Nishikawa Y, Miyazaki T, Nakashiro K, Yamagata H, Isokane M, Goda H, Tanaka H, Oka R and Hamakawa H: Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin. Oncol Rep 26: 587-592, 2011.
APA
Nishikawa, Y., Miyazaki, T., Nakashiro, K., Yamagata, H., Isokane, M., Goda, H. ... Hamakawa, H. (2011). Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin. Oncology Reports, 26, 587-592. https://doi.org/10.3892/or.2011.1324
MLA
Nishikawa, Y., Miyazaki, T., Nakashiro, K., Yamagata, H., Isokane, M., Goda, H., Tanaka, H., Oka, R., Hamakawa, H."Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin". Oncology Reports 26.3 (2011): 587-592.
Chicago
Nishikawa, Y., Miyazaki, T., Nakashiro, K., Yamagata, H., Isokane, M., Goda, H., Tanaka, H., Oka, R., Hamakawa, H."Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin". Oncology Reports 26, no. 3 (2011): 587-592. https://doi.org/10.3892/or.2011.1324
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