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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2011 Volume 26 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts

  • Authors:
    • Satoshi Takeuchi
    • Songji Zhao
    • Yuji Kuge
    • Yan Zhao
    • Ken-Ichi Nishijima
    • Toshiyuki Hatano
    • Yasushi Shimizu
    • Ichiro Kinoshita
    • Nagara Tamaki
    • Hirotoshi Dosaka-Akita

  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan, Central Institute of Isotope Science, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan
  • Pages: 725-730
    |
    Published online on: June 7, 2011
       https://doi.org/10.3892/or.2011.1338
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Abstract

We investigated whether 18F-fluorothymidine-positron-emission tomography/computed tomography (18F-FLT-PET/CT) is useful for the evaluation of the very early response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab therapy in human lung cancer xenografts. A human tumor xenograft model was established with a human non-small cell lung cancer cell line. The mice were randomly assigned to four groups: tumor growth follow-up, ex vivo study, PET/CT imaging and non-treated control. Mice were administered saline as control or cetuximab on day 1. An immunohistochemical study with Ki-67 was performed. Tumor volume treated with cetuximab was kept significantly smaller than control after day 8, although there was no difference on day 3. On day 3, 18F-FLT distribution was higher in the tumor than in other tissues, and was significantly decreased by treatment with cetuximab. On PET/CT imaging, 18F-FLT distribution in the tumor was clearly visualized, and the maximum standardized uptake value (SUV) was significantly decreased after treatment with cetuximab (p<0.01). Ki-67 expression was also significantly decreased on day 3 (p=0.01). These results suggest that 18F-FLT-PET/CT can be a useful predictor to determine the response to molecular targeted drugs such as cetuximab at an earlier time point than the change of tumor size.

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Copy and paste a formatted citation
Spandidos Publications style
Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima K, Hatano T, Shimizu Y, Kinoshita I, Tamaki N, Dosaka-Akita H, Dosaka-Akita H, et al: 18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts. Oncol Rep 26: 725-730, 2011.
APA
Takeuchi, S., Zhao, S., Kuge, Y., Zhao, Y., Nishijima, K., Hatano, T. ... Dosaka-Akita, H. (2011). 18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts. Oncology Reports, 26, 725-730. https://doi.org/10.3892/or.2011.1338
MLA
Takeuchi, S., Zhao, S., Kuge, Y., Zhao, Y., Nishijima, K., Hatano, T., Shimizu, Y., Kinoshita, I., Tamaki, N., Dosaka-Akita, H."18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts". Oncology Reports 26.3 (2011): 725-730.
Chicago
Takeuchi, S., Zhao, S., Kuge, Y., Zhao, Y., Nishijima, K., Hatano, T., Shimizu, Y., Kinoshita, I., Tamaki, N., Dosaka-Akita, H."18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts". Oncology Reports 26, no. 3 (2011): 725-730. https://doi.org/10.3892/or.2011.1338
Copy and paste a formatted citation
x
Spandidos Publications style
Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima K, Hatano T, Shimizu Y, Kinoshita I, Tamaki N, Dosaka-Akita H, Dosaka-Akita H, et al: 18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts. Oncol Rep 26: 725-730, 2011.
APA
Takeuchi, S., Zhao, S., Kuge, Y., Zhao, Y., Nishijima, K., Hatano, T. ... Dosaka-Akita, H. (2011). 18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts. Oncology Reports, 26, 725-730. https://doi.org/10.3892/or.2011.1338
MLA
Takeuchi, S., Zhao, S., Kuge, Y., Zhao, Y., Nishijima, K., Hatano, T., Shimizu, Y., Kinoshita, I., Tamaki, N., Dosaka-Akita, H."18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts". Oncology Reports 26.3 (2011): 725-730.
Chicago
Takeuchi, S., Zhao, S., Kuge, Y., Zhao, Y., Nishijima, K., Hatano, T., Shimizu, Y., Kinoshita, I., Tamaki, N., Dosaka-Akita, H."18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts". Oncology Reports 26, no. 3 (2011): 725-730. https://doi.org/10.3892/or.2011.1338
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