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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2011 Volume 26 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells

  • Authors:
    • Yoriko Yoshizawa
    • Yoshihiko Yamada
    • Seiji Kanayama
    • Hiroshi Shigetomi
    • Ryuji Kawaguchi
    • Shozo Yoshida
    • Akira Nagai
    • Naoto Furukawa
    • Hidekazu Oi
    • Hiroshi Kobayashi

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634-8522, Japan, Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan
  • Pages: 957-964
    |
    Published online on: June 15, 2011
       https://doi.org/10.3892/or.2011.1348
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Abstract

Hepatocyte growth factor (HGF) is up-regulated in tissue repair and has been implicated in playing a role in this process through its anti-apoptotic and proliferative activities. Cyclooxygenase-2 (COX-2) is an inducible enzyme in the biosynthetic pathway of prostaglandins, and its activation has been shown to play an important role in cell growth. We previously reported that HGF significantly inhibited anoikis, possibly through the up-regulation of COX-2 expression in the endometrial RL95-2 cancer cell line. Here, we report that i) treatment of RL95-2 cells with HGF resulted in phosphorylation of the HGF receptor c-Met, activation of Akt and IκB, translocation of NF-κB into the nucleus, and up-regulation of COX-2 mRNA; ii) the IκB-α phosphorylation inhibitor BAY11-7082 and the selective COX-2 inhibitor CAY10452 blocked HGF-mediated anoikis resistance in RL95-2 cells; and iii) HGF induced migration and invasion in RL95-2 cells, while the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and CAY10452 blocked these effects of HGF stimulation. Our data suggest that HGF possesses chemotactic ability, has anti-apoptosis action, and induces cellular infiltration via the PI3K/Akt pathway; it also triggers NF-κB activation and up-regulates COX-2 gene expression in endometrial cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshizawa Y, Yamada Y, Kanayama S, Shigetomi H, Kawaguchi R, Yoshida S, Nagai A, Furukawa N, Oi H, Kobayashi H, Kobayashi H, et al: Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells. Oncol Rep 26: 957-964, 2011.
APA
Yoshizawa, Y., Yamada, Y., Kanayama, S., Shigetomi, H., Kawaguchi, R., Yoshida, S. ... Kobayashi, H. (2011). Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells. Oncology Reports, 26, 957-964. https://doi.org/10.3892/or.2011.1348
MLA
Yoshizawa, Y., Yamada, Y., Kanayama, S., Shigetomi, H., Kawaguchi, R., Yoshida, S., Nagai, A., Furukawa, N., Oi, H., Kobayashi, H."Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells". Oncology Reports 26.4 (2011): 957-964.
Chicago
Yoshizawa, Y., Yamada, Y., Kanayama, S., Shigetomi, H., Kawaguchi, R., Yoshida, S., Nagai, A., Furukawa, N., Oi, H., Kobayashi, H."Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells". Oncology Reports 26, no. 4 (2011): 957-964. https://doi.org/10.3892/or.2011.1348
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshizawa Y, Yamada Y, Kanayama S, Shigetomi H, Kawaguchi R, Yoshida S, Nagai A, Furukawa N, Oi H, Kobayashi H, Kobayashi H, et al: Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells. Oncol Rep 26: 957-964, 2011.
APA
Yoshizawa, Y., Yamada, Y., Kanayama, S., Shigetomi, H., Kawaguchi, R., Yoshida, S. ... Kobayashi, H. (2011). Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells. Oncology Reports, 26, 957-964. https://doi.org/10.3892/or.2011.1348
MLA
Yoshizawa, Y., Yamada, Y., Kanayama, S., Shigetomi, H., Kawaguchi, R., Yoshida, S., Nagai, A., Furukawa, N., Oi, H., Kobayashi, H."Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells". Oncology Reports 26.4 (2011): 957-964.
Chicago
Yoshizawa, Y., Yamada, Y., Kanayama, S., Shigetomi, H., Kawaguchi, R., Yoshida, S., Nagai, A., Furukawa, N., Oi, H., Kobayashi, H."Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells". Oncology Reports 26, no. 4 (2011): 957-964. https://doi.org/10.3892/or.2011.1348
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