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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2011 Volume 26 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2011 Volume 26 Issue 4

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Article

Overexpression of SALL4 in lung cancer and its importance in cell proliferation

  • Authors:
    • Daisuke Kobayashi
    • Kageaki Kuribayashi
    • Maki Tanaka
    • Naoki Watanabe

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-Ku, Sapporo 060-8543, Japan
  • Pages: 965-970
    |
    Published online on: July 1, 2011
       https://doi.org/10.3892/or.2011.1374
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Abstract

Few target molecules have been identified that enable the diagnosis of lung cancer with high sensitivity and specificity, especially in the early clinical stages. Herein, we present the first evidence for mRNA overexpression of SALL4, a transcription factor essential for embryonic development and the self-renewal of embryonic stem cells, in lung cancer. Analysis using cancerous and noncancerous tissues revealed that the sensitivity and specificity of SALL4 mRNA were 85.1 and 92.9%, respectively, estimated using the cutoff value obtained from analyzing the receiver operating characteristic curve. Furthermore, comparison of paired tissues from the same patient revealed elevated SALL4 mRNA levels that were greater than two-fold in 93% of the specimens. SALL4 mRNA was highly expressed even in the early clinical stages and there was no difference in the positivity rate between stage IA and other stages. An siRNA approach to determine the significance of SALL4 expression revealed catastrophic growth inhibition of SBC-1 lung cancer cells that was induced by cell cycle arrest at the G1/early S phase. Therefore, SALL4 mRNA may be a candidate for use as support in the diagnosis of lung cancer, and may also represent a therapeutic target.

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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi D, Kuribayashi K, Tanaka M and Watanabe N: Overexpression of SALL4 in lung cancer and its importance in cell proliferation. Oncol Rep 26: 965-970, 2011.
APA
Kobayashi, D., Kuribayashi, K., Tanaka, M., & Watanabe, N. (2011). Overexpression of SALL4 in lung cancer and its importance in cell proliferation. Oncology Reports, 26, 965-970. https://doi.org/10.3892/or.2011.1374
MLA
Kobayashi, D., Kuribayashi, K., Tanaka, M., Watanabe, N."Overexpression of SALL4 in lung cancer and its importance in cell proliferation". Oncology Reports 26.4 (2011): 965-970.
Chicago
Kobayashi, D., Kuribayashi, K., Tanaka, M., Watanabe, N."Overexpression of SALL4 in lung cancer and its importance in cell proliferation". Oncology Reports 26, no. 4 (2011): 965-970. https://doi.org/10.3892/or.2011.1374
Copy and paste a formatted citation
x
Spandidos Publications style
Kobayashi D, Kuribayashi K, Tanaka M and Watanabe N: Overexpression of SALL4 in lung cancer and its importance in cell proliferation. Oncol Rep 26: 965-970, 2011.
APA
Kobayashi, D., Kuribayashi, K., Tanaka, M., & Watanabe, N. (2011). Overexpression of SALL4 in lung cancer and its importance in cell proliferation. Oncology Reports, 26, 965-970. https://doi.org/10.3892/or.2011.1374
MLA
Kobayashi, D., Kuribayashi, K., Tanaka, M., Watanabe, N."Overexpression of SALL4 in lung cancer and its importance in cell proliferation". Oncology Reports 26.4 (2011): 965-970.
Chicago
Kobayashi, D., Kuribayashi, K., Tanaka, M., Watanabe, N."Overexpression of SALL4 in lung cancer and its importance in cell proliferation". Oncology Reports 26, no. 4 (2011): 965-970. https://doi.org/10.3892/or.2011.1374
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