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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2011 Volume 26 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines

  • Authors:
    • Ioannis Mylonas
    • Darius Dian

  • View Affiliations / Copyright

    Affiliations: First Department of Obstetrics and Gynaecology, Ludwig Maximilian University of Munich, Maistrasse 11, D-80337 Munich, Germany
  • Pages: 887-891
    |
    Published online on: July 4, 2011
       https://doi.org/10.3892/or.2011.1379
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Abstract

Inhibins are dimeric glycoproteins composed of an α‑subunit and one of two possible β-subunits (βA or βB), with substantial roles in human reproduction and in endocrine-responsive tumours. Four normal cervical tissue samples together with 10 specimens of well-differentiated squamous cervical cancer and adenocarcinoma of the cervix were immunohistochemically analysed for the expression of the inhibin‑α subunit. Additionally, two cervical carcinoma cell lines (HeLa and CaSKi) were analysed with immunofluorescence and RT-PCR for the expression of the inhibin‑α subunit. We demonstrated for the first time an immunolabelling of the inhibin‑α subunit in normal and malignant cervical tissue, as well as cervical cancer cells. However, the immunoreactive reaction was albeit weak and mostly confined to mitotic cells in the analysed cervical tissues. Additionally, the expression pattern of this subunit was rather inconsistent. Therefore, the immunohistochemical evaluation of this subunit in cervical tissue cannot be used as a prognostic marker as suggested for endometrial cancer. However, since the expression of the inhibin‑α subunit is minimal in HeLa cells as assessed by immunofluorescence and RT-PCR, the CaSKi cell line might be a better model for further functional experiments regarding cervical pathogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Mylonas I and Dian D: Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines. Oncol Rep 26: 887-891, 2011.
APA
Mylonas, I., & Dian, D. (2011). Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines. Oncology Reports, 26, 887-891. https://doi.org/10.3892/or.2011.1379
MLA
Mylonas, I., Dian, D."Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines". Oncology Reports 26.4 (2011): 887-891.
Chicago
Mylonas, I., Dian, D."Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines". Oncology Reports 26, no. 4 (2011): 887-891. https://doi.org/10.3892/or.2011.1379
Copy and paste a formatted citation
x
Spandidos Publications style
Mylonas I and Dian D: Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines. Oncol Rep 26: 887-891, 2011.
APA
Mylonas, I., & Dian, D. (2011). Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines. Oncology Reports, 26, 887-891. https://doi.org/10.3892/or.2011.1379
MLA
Mylonas, I., Dian, D."Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines". Oncology Reports 26.4 (2011): 887-891.
Chicago
Mylonas, I., Dian, D."Inhibin-α subunit in normal and malignant human cervical tissue and cervical cancer cell lines". Oncology Reports 26, no. 4 (2011): 887-891. https://doi.org/10.3892/or.2011.1379
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