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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2011 Volume 26 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo

  • Authors:
    • Mingxuan Xie
    • Qiong Chen
    • Shuya He
    • Baoshun Li
    • Chengping Hu

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Department of Gerontology, Xiangya Hospital, Central South University, Changsha 410008, P.R. China, Department of Respiratory Medicine, Department of Gerontology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, P.R. China
  • Pages: 1019-1027
    |
    Published online on: July 8, 2011
       https://doi.org/10.3892/or.2011.1383
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Abstract

Human telomerase reverse transcriptase (hTERT) is the catalytic subunit and the activity determinant factor of the telomerase enzyme which maintains the length of human chromosomes. In recent years it has become an attractive molecular target for cancer gene therapy. In the present study, we show that hTERT siRNA effectively suppressed the expression of hTERT mRNA and hTERT protein levels, reduced telomerase activity, and induced apoptosis of A549 lung adenocarcinoma cells (P<0.05). In vivo, tumors treated with the hTERT siRNA were of reduced sizes, indicating that the hTERT siRNA also reduced the tumorigenic potential of lung adenocarcinoma cells (P<0.05). These results demonstrate that hTERT siRNA can cause effective suppression of telomerase and lead to apoptosis in A549 lung adenocarcinoma cells. hTERT siRNA may, therefore, be a strong candidate for highly selective therapy for chemoprevention and treatment of lung adenocarcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Xie M, Chen Q, He S, Li B and Hu C: Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo. Oncol Rep 26: 1019-1027, 2011.
APA
Xie, M., Chen, Q., He, S., Li, B., & Hu, C. (2011). Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo. Oncology Reports, 26, 1019-1027. https://doi.org/10.3892/or.2011.1383
MLA
Xie, M., Chen, Q., He, S., Li, B., Hu, C."Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo". Oncology Reports 26.4 (2011): 1019-1027.
Chicago
Xie, M., Chen, Q., He, S., Li, B., Hu, C."Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo". Oncology Reports 26, no. 4 (2011): 1019-1027. https://doi.org/10.3892/or.2011.1383
Copy and paste a formatted citation
x
Spandidos Publications style
Xie M, Chen Q, He S, Li B and Hu C: Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo. Oncol Rep 26: 1019-1027, 2011.
APA
Xie, M., Chen, Q., He, S., Li, B., & Hu, C. (2011). Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo. Oncology Reports, 26, 1019-1027. https://doi.org/10.3892/or.2011.1383
MLA
Xie, M., Chen, Q., He, S., Li, B., Hu, C."Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo". Oncology Reports 26.4 (2011): 1019-1027.
Chicago
Xie, M., Chen, Q., He, S., Li, B., Hu, C."Silencing of the human TERT gene by RNAi inhibits A549 lung adenocarcinoma cell growth in vitro and in vivo". Oncology Reports 26, no. 4 (2011): 1019-1027. https://doi.org/10.3892/or.2011.1383
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