Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: An unfavorable and independent prognostic factor

  • Authors:
    • Wei Sun
    • Yue-Zu Fan
    • Hao Xi
    • Xing-Sui Lu
    • Chun Ye
    • Jing-Tao Zhang
  • View Affiliations

  • Published online on: July 11, 2011     https://doi.org/10.3892/or.2011.1387
  • Pages: 1133-1142
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Abstract

Astrocyte elevated gene-1 (AEG-1), as an HIV-1 or TNF-α-inducible transcript, is correlated with various aspects of tumor malignancy. However, the status of AEG-1 expression and its clinical significance in human gallbladder carcinoma (GBC) remains unknown. In the present study, we investigated AEG-1 expression in two GBC cell lines (GBC-SD and SGC-996) and GBC tissues by immunohisto­chemical, Western blot and real-time PCR analysis. We found that AEG-1 was highly expressed in GBC samples (63.4%, 26 of 41) compared with normal gallbladder mucosa (p=0.0003) and highly invasive GBC-SD cell lines at both the protein (p=0.0043) and mRNA levels (p=0.0001), and strongly correlated with differentiation degree (p=0.006), Nevin stage (p=0.0344), Ki‑67 expression (p=0.0024) and liver infiltration (p=0.0332) in these patients. Multivariate analysis indicated that AEG-1 overexpression was an independent prognostic marker for GBC patients. Moreover, patients with high AEG-1 levels had shorter survival time (p=0.008). Our results suggest that the AEG-1 protein is a valuable marker of GBC progression and could be a potential therapeutic target.

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November 2011
Volume 26 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sun W, Fan Y, Xi H, Lu X, Ye C and Zhang J: Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: An unfavorable and independent prognostic factor. Oncol Rep 26: 1133-1142, 2011
APA
Sun, W., Fan, Y., Xi, H., Lu, X., Ye, C., & Zhang, J. (2011). Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: An unfavorable and independent prognostic factor. Oncology Reports, 26, 1133-1142. https://doi.org/10.3892/or.2011.1387
MLA
Sun, W., Fan, Y., Xi, H., Lu, X., Ye, C., Zhang, J."Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: An unfavorable and independent prognostic factor". Oncology Reports 26.5 (2011): 1133-1142.
Chicago
Sun, W., Fan, Y., Xi, H., Lu, X., Ye, C., Zhang, J."Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: An unfavorable and independent prognostic factor". Oncology Reports 26, no. 5 (2011): 1133-1142. https://doi.org/10.3892/or.2011.1387