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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 26 Issue 5

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Article

Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells

  • Authors:
    • Shudong Yu
    • Ruxin Zhang
    • Fenye Liu
    • Hua Hu
    • Shaoqing Yu
    • Hong Wang

  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Otolaryn­gology, Huadong Hospital, Fudan University, 221 Yan An Xi Road, Shanghai 200040, P.R. China
  • Pages: 1323-1328
    |
    Published online on: July 26, 2011
       https://doi.org/10.3892/or.2011.1402
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Abstract

Currently, the main approach to nasopharyngeal carcinoma (NPC) treatment is radiotherapy (RT), but for many NPC patients, RT is not effective. Increasing RT sensitivity of NPC cells would provide a significant treatment advance for NPC patients. While γ-secretase inhibitors (GSIs) have gained recent attention as novel anticancer drugs, the mechanism of action of GSIs as radiosensitizers is not well understood. In the present study, radiation-induced anti-proliferative effects of the one GSI (N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester, DAPT), on CNE2 cells were investigated with the MTT assay; in vitro radiosensitization effects were evaluated by the apoptosis assay and the cell colony formation assay. The activation status of the Notch signaling pathway in DAPT- or dimethyl sulfoxide-treated CNE2 cells was also examined. Notch signaling in NPC cells was found to be down-regulated by DAPT; therefore, DAPT could significantly inhibit CNE2 growth and improve NPC radiosensitization, thus, enhancing RT-induced anti-proliferative effects and apoptosis. Taken together, our data show that Notch signaling down-regulation by GSIs could enhance radiosensitivity of NPC cells, suggesting clinical applications for GSIs as radiosensitizers for NPC therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Yu S, Zhang R, Liu F, Hu H, Yu S and Wang H: Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells. Oncol Rep 26: 1323-1328, 2011.
APA
Yu, S., Zhang, R., Liu, F., Hu, H., Yu, S., & Wang, H. (2011). Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells. Oncology Reports, 26, 1323-1328. https://doi.org/10.3892/or.2011.1402
MLA
Yu, S., Zhang, R., Liu, F., Hu, H., Yu, S., Wang, H."Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells". Oncology Reports 26.5 (2011): 1323-1328.
Chicago
Yu, S., Zhang, R., Liu, F., Hu, H., Yu, S., Wang, H."Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells". Oncology Reports 26, no. 5 (2011): 1323-1328. https://doi.org/10.3892/or.2011.1402
Copy and paste a formatted citation
x
Spandidos Publications style
Yu S, Zhang R, Liu F, Hu H, Yu S and Wang H: Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells. Oncol Rep 26: 1323-1328, 2011.
APA
Yu, S., Zhang, R., Liu, F., Hu, H., Yu, S., & Wang, H. (2011). Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells. Oncology Reports, 26, 1323-1328. https://doi.org/10.3892/or.2011.1402
MLA
Yu, S., Zhang, R., Liu, F., Hu, H., Yu, S., Wang, H."Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells". Oncology Reports 26.5 (2011): 1323-1328.
Chicago
Yu, S., Zhang, R., Liu, F., Hu, H., Yu, S., Wang, H."Down-regulation of Notch signaling by a γ-secretase inhibitor enhances the radiosensitivity of nasopharyngeal carcinoma cells". Oncology Reports 26, no. 5 (2011): 1323-1328. https://doi.org/10.3892/or.2011.1402
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