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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 26 Issue 5

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Article

Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages

  • Authors:
    • Aurélie Perraud
    • Hussein Akil
    • Michelle Nouaille
    • Daniel Petit
    • François Labrousse
    • Marie-Odile Jauberteau
    • Muriel Mathonnet

  • View Affiliations / Copyright

    Affiliations: Laboratoire EA 3842, Homéostasie Cellulaire et Pathologies, Faculté de Médecine et de Pharmacie, Université de Limoges, 2 rue du Dr Marcland, 87025 Limoges Cedex, France
  • Pages: 1091-1097
    |
    Published online on: July 26, 2011
       https://doi.org/10.3892/or.2011.1404
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Abstract

Apoptosis has to be drastically controlled in organs with important cell turnover such as the colon. Deregulation of this process is often present in tumor progression. Tissues of 82 patients treated for colorectal cancer (CRC) were analyzed using antibodies against AIF, p53, DR4, DR5, cleaved caspase-3 and the TUNEL method to detect apoptosis; whereas staining of Ki-67 was used as a proliferation marker. In situ immunohistochemical analyses were compared in non-tumor (NT) cells from normal adjacent mucous membranes with tumor (T) cells from patients with Stage I (n=6), Stage II (n=35), Stage III (n=27) and Stage IV (n=14) CRC. Results were correlated with the tumor stages and the treatment response of patients to improve the understanding of CRC development. p53 and DR5 expression decreased progressively with CRC stage, suggesting that these proteins are important markers of advanced tumor stages. Moreover, p53 appears as a prognostic factor to predict recurrence-free survival. Including the detection of p53 and DR5 for establishing the diagnosis of CRC and adapting the treatment to each patient is strongly suggested by our work.

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Copy and paste a formatted citation
Spandidos Publications style
Perraud A, Akil H, Nouaille M, Petit D, Labrousse F, Jauberteau M and Mathonnet M: Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages. Oncol Rep 26: 1091-1097, 2011.
APA
Perraud, A., Akil, H., Nouaille, M., Petit, D., Labrousse, F., Jauberteau, M., & Mathonnet, M. (2011). Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages. Oncology Reports, 26, 1091-1097. https://doi.org/10.3892/or.2011.1404
MLA
Perraud, A., Akil, H., Nouaille, M., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages". Oncology Reports 26.5 (2011): 1091-1097.
Chicago
Perraud, A., Akil, H., Nouaille, M., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages". Oncology Reports 26, no. 5 (2011): 1091-1097. https://doi.org/10.3892/or.2011.1404
Copy and paste a formatted citation
x
Spandidos Publications style
Perraud A, Akil H, Nouaille M, Petit D, Labrousse F, Jauberteau M and Mathonnet M: Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages. Oncol Rep 26: 1091-1097, 2011.
APA
Perraud, A., Akil, H., Nouaille, M., Petit, D., Labrousse, F., Jauberteau, M., & Mathonnet, M. (2011). Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages. Oncology Reports, 26, 1091-1097. https://doi.org/10.3892/or.2011.1404
MLA
Perraud, A., Akil, H., Nouaille, M., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages". Oncology Reports 26.5 (2011): 1091-1097.
Chicago
Perraud, A., Akil, H., Nouaille, M., Petit, D., Labrousse, F., Jauberteau, M., Mathonnet, M."Expression of p53 and DR5 in normal and malignant tissues of colorectal cancer: Correlation with advanced stages". Oncology Reports 26, no. 5 (2011): 1091-1097. https://doi.org/10.3892/or.2011.1404
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