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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy

  • Authors:
    • Susumu Saigusa
    • Yasuhiko Mohri
    • Masaki Ohi
    • Yuji Toiyama
    • Yoshito Ishino
    • Yoshinaga Okugawa
    • Koji Tanaka
    • Yasuhiro Inoue
    • Masato Kusunoki

  • View Affiliations / Copyright

    Affiliations: Department of Gastro­intestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
  • Pages: 1069-1074
    |
    Published online on: August 2, 2011
       https://doi.org/10.3892/or.2011.1408
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Abstract

Neoadjuvant chemo-radiotherapy (CRT) followed by surgery are the standard approaches for locally advanced esophageal cancer. However, the overall cure rate is very low. The aim of this preliminary study was to evaluate the expression of podoplanin and SOX2 known as stemness markers for esophageal squamous cell carcinoma (ESCC) and their association with clinical outcome. We obtained a total of 20 specimens from patients with ESCC who underwent neoadjuvant CRT (30-40 Gy; 5-fluorouracil plus cisplatin) followed by surgery. Podoplanin and SOX2 expression was evaluated using immunohistochemistry and the association of their expressions with clinicopathological variables was investigated. Podoplanin and SOX2 staining was detected not only in residual cancer cells, but also in the basal layer of adjacent normal mucosa after neoadjuvant CRT. High expression of podoplanin was correlated with lymph node metastasis, advanced postoperative stage and vascular invasion (P<0.05), while, high expression of SOX2 was correlated with lymphatic, vascular invasion, poor differentiated tumor and incomplete resection (P<0.05). High expression of podoplanin was significantly associated with poor overall survival (P<0.05). In conclusion, the expression levels of podoplanin and SOX2 expression may be useful prognostic markers for ESCC treated with neoadjuvant CRT.

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Copy and paste a formatted citation
Spandidos Publications style
Saigusa S, Mohri Y, Ohi M, Toiyama Y, Ishino Y, Okugawa Y, Tanaka K, Inoue Y and Kusunoki M: Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy. Oncol Rep 26: 1069-1074, 2011.
APA
Saigusa, S., Mohri, Y., Ohi, M., Toiyama, Y., Ishino, Y., Okugawa, Y. ... Kusunoki, M. (2011). Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy. Oncology Reports, 26, 1069-1074. https://doi.org/10.3892/or.2011.1408
MLA
Saigusa, S., Mohri, Y., Ohi, M., Toiyama, Y., Ishino, Y., Okugawa, Y., Tanaka, K., Inoue, Y., Kusunoki, M."Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy". Oncology Reports 26.5 (2011): 1069-1074.
Chicago
Saigusa, S., Mohri, Y., Ohi, M., Toiyama, Y., Ishino, Y., Okugawa, Y., Tanaka, K., Inoue, Y., Kusunoki, M."Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy". Oncology Reports 26, no. 5 (2011): 1069-1074. https://doi.org/10.3892/or.2011.1408
Copy and paste a formatted citation
x
Spandidos Publications style
Saigusa S, Mohri Y, Ohi M, Toiyama Y, Ishino Y, Okugawa Y, Tanaka K, Inoue Y and Kusunoki M: Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy. Oncol Rep 26: 1069-1074, 2011.
APA
Saigusa, S., Mohri, Y., Ohi, M., Toiyama, Y., Ishino, Y., Okugawa, Y. ... Kusunoki, M. (2011). Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy. Oncology Reports, 26, 1069-1074. https://doi.org/10.3892/or.2011.1408
MLA
Saigusa, S., Mohri, Y., Ohi, M., Toiyama, Y., Ishino, Y., Okugawa, Y., Tanaka, K., Inoue, Y., Kusunoki, M."Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy". Oncology Reports 26.5 (2011): 1069-1074.
Chicago
Saigusa, S., Mohri, Y., Ohi, M., Toiyama, Y., Ishino, Y., Okugawa, Y., Tanaka, K., Inoue, Y., Kusunoki, M."Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy". Oncology Reports 26, no. 5 (2011): 1069-1074. https://doi.org/10.3892/or.2011.1408
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