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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2011 Volume 26 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2011 Volume 26 Issue 6

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Article

β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression

  • Authors:
    • Penghui Zhang
    • Xiaoyan He
    • Junjie Tan
    • Xiaoyan Zhou
    • Lin Zou

  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory Center, Children's Hospital, Chongqing Medical University, Chongqing, P.R. China, Center for Clinical Molecular Medicine, Children's Hospital, Chongqing Medical University, Chongqing 400014, P.R. China
  • Pages: 1471-1477
    |
    Published online on: August 10, 2011
       https://doi.org/10.3892/or.2011.1417
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Abstract

The expression of the β-2 adrenergic receptor (β2AR), one of the stress-inducible receptors, has been reported to be closely correlated with malignant tumors. Prostate cancer is the most common non-cutaneous cancer among males, accompanied with increased castration levels and β2AR activation in patients. However, the role of β2AR activation in prostate cancer cells and its underlying mechanisms are not fully understood. Here, we found that β2AR activation promoted cell proliferation and cell migration through increasing cellular adenylyl cyclase (cAMP) levels and ERK1/2 activation in LNCaP and PC3 prostate cancer cells. Moreover, the scaffold protein β-arrestin2 was found to be involved in the β2AR-mediated activation of ERK1/2 and cell proliferation using stable overexpressing β-arrestin2 LNCaP (LNCaP-βArr2) cells. Furthermore, enhanced β-arrestin2/c-Src complex formation by β2AR activation was observed in LNCaP-βArr2 cells. In addition, the c-Src inhibitor could block this enhanced complex formation and suppressed cell proliferation. This study demonstrates that βArr2 is involved in prostate carcinogenesis induced by stress and provides potential therapeutic targets for cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang P, He X, Tan J, Zhou X and Zou L: β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression. Oncol Rep 26: 1471-1477, 2011.
APA
Zhang, P., He, X., Tan, J., Zhou, X., & Zou, L. (2011). β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression. Oncology Reports, 26, 1471-1477. https://doi.org/10.3892/or.2011.1417
MLA
Zhang, P., He, X., Tan, J., Zhou, X., Zou, L."β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression". Oncology Reports 26.6 (2011): 1471-1477.
Chicago
Zhang, P., He, X., Tan, J., Zhou, X., Zou, L."β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression". Oncology Reports 26, no. 6 (2011): 1471-1477. https://doi.org/10.3892/or.2011.1417
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, He X, Tan J, Zhou X and Zou L: β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression. Oncol Rep 26: 1471-1477, 2011.
APA
Zhang, P., He, X., Tan, J., Zhou, X., & Zou, L. (2011). β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression. Oncology Reports, 26, 1471-1477. https://doi.org/10.3892/or.2011.1417
MLA
Zhang, P., He, X., Tan, J., Zhou, X., Zou, L."β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression". Oncology Reports 26.6 (2011): 1471-1477.
Chicago
Zhang, P., He, X., Tan, J., Zhou, X., Zou, L."β-arrestin2 mediates β-2 adrenergic receptor signaling inducing prostate cancer cell progression". Oncology Reports 26, no. 6 (2011): 1471-1477. https://doi.org/10.3892/or.2011.1417
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