Highly sensitive lens culinaris agglutinin-reactive α-fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease

  • Authors:
    • Kohei Oda
    • Akio Ido
    • Tsutomu Tamai
    • Masakaze Matsushita
    • Kotaro Kumagai
    • Sei-ichi Mawatari
    • Akiko Saishoji
    • Takeshi Kure
    • Kaori Ohno
    • Eriko Toyokura
    • Dai Imanaka
    • Akihiro Moriuchi
    • Hirofumi Uto
    • Makoto Oketani
    • Teruto Hashiguchi
    • Hirohito Tsubouchi
  • View Affiliations

  • Published online on: August 19, 2011     https://doi.org/10.3892/or.2011.1425
  • Pages: 1227-1233
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Abstract

The fucosylated fraction of α-fetoprotein (AFP-L3) is a specific marker for hepatocellular carcinoma (HCC). However, conventional AFP-L3% (c-AFP-L3%) has not always been reliable in cases with low serum α-fetoprotein (AFP) levels. In this study, we evaluated the clinical utility of a newly developed assay, highly sensitive AFP-L3% (hs-AFP-L3%). Subjects included 74 patients with benign liver disease (BLD), including chronic hepatitis and cirrhosis, and 94 with HCC. Serum hs-AFP-L3% was significantly higher than c-AFP-L3% in patients with early-stage HCC (solitary or <20 mm in diameter). Additionally, hs-AFP-L3% was significantly increased in patients with well-differentiated HCC. In patients with serum AFP <20 ng/ml, the sensitivities of c-AFP-L3% and hs-AFP-L3% were 12.5 and 44.6%, respectively, at a cut-off value of 5%. In 59 BLD patients with serum AFP <20 ng/ml, the HCC-positive rate in patients with hs-AFP-L3% ≥5% was significantly higher compared to those with hs-AFP-L3% <5% during the follow-up period (median, 35 months; range, 5-48 months). Importantly, none of the BLD patients with both serum AFP <20 ng/ml and hs-AFP-L3% <5% developed HCC. These results indicated that hs-AFP-L3% is useful for early detection of HCC in BLD patients, even for those with serum AFP <20 ng/ml. Furthermore, since hs-AFP-L3% increases before HCC is detectable by various advanced imaging modalities, this assay may help identify BLD patients with a higher risk of HCC.

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November 2011
Volume 26 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Oda, K., Ido, A., Tamai, T., Matsushita, M., Kumagai, K., Mawatari, S. ... Tsubouchi, H. (2011). Highly sensitive lens culinaris agglutinin-reactive α-fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease. Oncology Reports, 26, 1227-1233. https://doi.org/10.3892/or.2011.1425
MLA
Oda, K., Ido, A., Tamai, T., Matsushita, M., Kumagai, K., Mawatari, S., Saishoji, A., Kure, T., Ohno, K., Toyokura, E., Imanaka, D., Moriuchi, A., Uto, H., Oketani, M., Hashiguchi, T., Tsubouchi, H."Highly sensitive lens culinaris agglutinin-reactive α-fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease". Oncology Reports 26.5 (2011): 1227-1233.
Chicago
Oda, K., Ido, A., Tamai, T., Matsushita, M., Kumagai, K., Mawatari, S., Saishoji, A., Kure, T., Ohno, K., Toyokura, E., Imanaka, D., Moriuchi, A., Uto, H., Oketani, M., Hashiguchi, T., Tsubouchi, H."Highly sensitive lens culinaris agglutinin-reactive α-fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease". Oncology Reports 26, no. 5 (2011): 1227-1233. https://doi.org/10.3892/or.2011.1425