MHC class II genotype- and MHC class I and II phenotype-related parameters in sporadic colorectal cancer

  • Authors:
    • Toralf Wolkersdörfer
    • Monika Füssel
    • Tobias Kiesslich
    • Daniel Neureiter
    • Frieder Berr
    • Daniela Aust
    • Gernot W. Wolkersdörfer
  • View Affiliations

  • Published online on: August 19, 2011     https://doi.org/10.3892/or.2011.1427
  • Pages: 1165-1171
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Abstract

The underlying etiological cause of non-hereditary colorectal cancer has yet to be determined. The adenoma-carcinoma sequence is widely accepted, however, a sole trigger has not been specified. Therefore, we sought to further define genotypic and phenotypic parameters that could be involved in promoting a possible infection, inflammation and hyper­proliferation, followed by the adenoma-carcinoma sequence. Expression of phenotype-related parameters for MHC class I (HLA‑A N-20 and β2 microglobulin) and class II (HLA‑DRα and HLA‑DR) as well as CD45 and carcinoembryonic antigen (CEA) were investigated immunohistochemically in a series of 93 colorectal cancers. Additionally, in 49 of the tumours the MHC class II genotype was analysed. MHC class II genotype analyses revealed a tendency towards DRB1*08 and DQB1*04. A significant association among the MHC class I markers or the MHC class II markers was found. No difference in marker expression could be detected between tumour and stromal tissue, however a significant inverse expression existed for markers of the functionally different class I or II systems. With the exception of CEA, there was no correlation between expression of any marker and tumour grade. Only 2% of tumours expressed no markers for MHC class I and II. Further studies on MHC class I and II genotype and phenotype relation in colorectal cancer may help to identify trigger mechanisms for tumourigenesis, involved markers and possible mechanisms of subsequent immune escape.

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November 2011
Volume 26 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wolkersdörfer T, Füssel M, Kiesslich T, Neureiter D, Berr F, Aust D and Wolkersdörfer GW: MHC class II genotype- and MHC class I and II phenotype-related parameters in sporadic colorectal cancer. Oncol Rep 26: 1165-1171, 2011
APA
Wolkersdörfer, T., Füssel, M., Kiesslich, T., Neureiter, D., Berr, F., Aust, D., & Wolkersdörfer, G.W. (2011). MHC class II genotype- and MHC class I and II phenotype-related parameters in sporadic colorectal cancer. Oncology Reports, 26, 1165-1171. https://doi.org/10.3892/or.2011.1427
MLA
Wolkersdörfer, T., Füssel, M., Kiesslich, T., Neureiter, D., Berr, F., Aust, D., Wolkersdörfer, G. W."MHC class II genotype- and MHC class I and II phenotype-related parameters in sporadic colorectal cancer". Oncology Reports 26.5 (2011): 1165-1171.
Chicago
Wolkersdörfer, T., Füssel, M., Kiesslich, T., Neureiter, D., Berr, F., Aust, D., Wolkersdörfer, G. W."MHC class II genotype- and MHC class I and II phenotype-related parameters in sporadic colorectal cancer". Oncology Reports 26, no. 5 (2011): 1165-1171. https://doi.org/10.3892/or.2011.1427