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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2011 Volume 26 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers

  • Authors:
    • Takashi Kakimoto
    • Ryosuke Shiraishi
    • Ryuichi Iwakiri
    • Kazuma Fujimoto
    • Hirokazu Takahashi
    • Hiroshi Hamajima
    • Toshihiko Mizuta
    • Hiroyuki Ideguchi
    • Shuji Toda
    • Yoshihiko Kitajima
    • Iwata Ozaki
    • Sachiko Matsuhashi

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan
  • Pages: 1385-1392
    |
    Published online on: September 5, 2011
       https://doi.org/10.3892/or.2011.1450
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Abstract

The expression patterns of PDCD4, a tumor suppressor, and β-catenin were immunohistologically investigated in gastric carcinoma tissues. In normal gastric tissues, PDCD4 was strongly expressed in the cell nuclei, but weakly expressed in the cytoplasm. In gastric adenocarcinoma tissues, nuclear PDCD4 expression was decreased, while cytoplasmic PDCD4 expression was unchanged or somewhat increased. In gastric signet ring cell carcinoma tissues, PDCD4 expression patterns were different from the expression patterns of the adenocarcinoma tissues, and PDCD4 was localized in the nuclei of the carcinoma cells as a belt in the middle of the epithelial layer. The nuclear localization of PDCD4 in the adenocarcinoma tissues was correlated with the membrane localization of β-catenin, the activation of which stimulates invasion of colon cancer cells. PDCD4 expression was correlated with β-catenin expression in gastric carcinoma cell lines, but not with E-cadherin, as the binding partner in the cell membrane.

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Copy and paste a formatted citation
Spandidos Publications style
Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Kitajima Y, et al: Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers. Oncol Rep 26: 1385-1392, 2011.
APA
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H. ... Matsuhashi, S. (2011). Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers. Oncology Reports, 26, 1385-1392. https://doi.org/10.3892/or.2011.1450
MLA
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H., Mizuta, T., Ideguchi, H., Toda, S., Kitajima, Y., Ozaki, I., Matsuhashi, S."Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers". Oncology Reports 26.6 (2011): 1385-1392.
Chicago
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H., Mizuta, T., Ideguchi, H., Toda, S., Kitajima, Y., Ozaki, I., Matsuhashi, S."Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers". Oncology Reports 26, no. 6 (2011): 1385-1392. https://doi.org/10.3892/or.2011.1450
Copy and paste a formatted citation
x
Spandidos Publications style
Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Kitajima Y, et al: Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers. Oncol Rep 26: 1385-1392, 2011.
APA
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H. ... Matsuhashi, S. (2011). Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers. Oncology Reports, 26, 1385-1392. https://doi.org/10.3892/or.2011.1450
MLA
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H., Mizuta, T., Ideguchi, H., Toda, S., Kitajima, Y., Ozaki, I., Matsuhashi, S."Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers". Oncology Reports 26.6 (2011): 1385-1392.
Chicago
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H., Mizuta, T., Ideguchi, H., Toda, S., Kitajima, Y., Ozaki, I., Matsuhashi, S."Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers". Oncology Reports 26, no. 6 (2011): 1385-1392. https://doi.org/10.3892/or.2011.1450
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