Molecular genetics and epidemiology of epithelial ovarian cancer (Review)

  • Authors:
    • Shoji Haruta
    • Naoto Furukawa
    • Yoriko Yoshizawa
    • Taihei Tsunemi
    • Akira Nagai
    • Ryuji Kawaguchi
    • Yasuhito Tanase
    • Shozo Yoshida
    • Hiroshi Kobayashi
  • View Affiliations

  • Published online on: September 12, 2011     https://doi.org/10.3892/or.2011.1456
  • Pages: 1347-1356
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Abstract

This review summarizes data from recent molecular genetic and epidemiology studies of the generic term ‘female pelvic cancer’. The English-language literature was reviewed for genetic, epigenetic, epidemiologic and environmental risk factors. There are well-documented disparities among racial and ethnic groups with respect to epithelial ovarian cancer (EOC) prevalence. In the case of the serous histological subtype, primary EOC, fallopian tube cancer and peritoneal cancer could be regarded as a single disease entity. However, EOC is not a single disease. Comparing the profile of EOC between Japanese and Caucasians, clear cell carcinomas (27.6%) are more common in Japan, possibly with fewer serous adenocarcinomas (40.7%). This may reflect a proportional increase. The Japanese may exhibit a higher proportion of malignant transformation of endometriosis compared to the United States population. Although some part of the molecular genetic pathogenesis has been unveiled, the complete events of molecular genetic epidemiological changes associated with EOC remain to be identified. This review focuses on current knowledge of the genetic and environmental factors affecting the development of EOC, and outlines future challenges in its pathogenesis research.

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December 2011
Volume 26 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Haruta S, Furukawa N, Yoshizawa Y, Tsunemi T, Nagai A, Kawaguchi R, Tanase Y, Yoshida S and Kobayashi H: Molecular genetics and epidemiology of epithelial ovarian cancer (Review). Oncol Rep 26: 1347-1356, 2011
APA
Haruta, S., Furukawa, N., Yoshizawa, Y., Tsunemi, T., Nagai, A., Kawaguchi, R. ... Kobayashi, H. (2011). Molecular genetics and epidemiology of epithelial ovarian cancer (Review). Oncology Reports, 26, 1347-1356. https://doi.org/10.3892/or.2011.1456
MLA
Haruta, S., Furukawa, N., Yoshizawa, Y., Tsunemi, T., Nagai, A., Kawaguchi, R., Tanase, Y., Yoshida, S., Kobayashi, H."Molecular genetics and epidemiology of epithelial ovarian cancer (Review)". Oncology Reports 26.6 (2011): 1347-1356.
Chicago
Haruta, S., Furukawa, N., Yoshizawa, Y., Tsunemi, T., Nagai, A., Kawaguchi, R., Tanase, Y., Yoshida, S., Kobayashi, H."Molecular genetics and epidemiology of epithelial ovarian cancer (Review)". Oncology Reports 26, no. 6 (2011): 1347-1356. https://doi.org/10.3892/or.2011.1456