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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2012 Volume 27 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2012 Volume 27 Issue 1

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Article

Regression of A549 lung cancer tumors by anti-miR-150 vector

  • Authors:
    • You-Jie Li
    • Yan-Xia Zhang
    • Ping-Yu Wang
    • Yong-Liang Chi
    • Chao Zhang
    • Ying Ma
    • Chang-Jun Lv
    • Shu-Yang Xie

  • View Affiliations / Copyright

    Affiliations: Institute of Medical Molecular Genetics, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yan Tai 264003, P.R. China, The Affiliated Hospital to Binzhou Medical University, Binzhou 256603, P.R. China, Institute of Medical Molecular Genetics, Department of Biochemistry and Molecular Biology, Binzhou Medical University, 346 Guan Hai Road, Lai Shan District, Yan Tai 264003, P.R. China
  • Pages: 129-134
    |
    Published online on: September 20, 2011
       https://doi.org/10.3892/or.2011.1466
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Abstract

microRNAs (miRNAs) have been shown to play a role in cancer. Antisense oligonucleotides can bind directly to miRNAs and block their activity, which are generally named anti-miRNAs. To suppress A549 cell proliferation in vitro and in vivo by anti-miRNAs, an anti-miR-150 expression vector (PR-ASO-150), regulated by the H1 promoter and containing a ‘TTTTT’ sequence following a hairpin to stop transcription, was constructed. A549 cell proliferation in vitro or in nude mice was observed after PR-ASO-150 treatment. Our results showed that miR-150 expression was inhibited and the growth inhibition rate of A549 cells was higher in the PR-ASO-150-treated group compared with the control, which indicated that PR-ASO-150 could inhibit A549 cell proliferation by regulating miR-150 expression. Following establishment of A549 cancer cell xenografts in nude mice, PR-ASO-150 was delivered intratumorally to investigate the suppressive action to tumor proliferation by regulating miR-150 expression. The results indicate that the tumor volume and weight were lower compared to the control group. Our results further showed that p53 expression was higher after tumor tissue was treated with PR-ASO-150, indicating that up-regulation of p53 contributed to the suppression to tumor growth. Our study provides a novel strategy for cancer therapy through the development of anti-miRNAs.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Zhang Y, Wang P, Chi Y, Zhang C, Ma Y, Lv C and Xie S: Regression of A549 lung cancer tumors by anti-miR-150 vector . Oncol Rep 27: 129-134, 2012.
APA
Li, Y., Zhang, Y., Wang, P., Chi, Y., Zhang, C., Ma, Y. ... Xie, S. (2012). Regression of A549 lung cancer tumors by anti-miR-150 vector . Oncology Reports, 27, 129-134. https://doi.org/10.3892/or.2011.1466
MLA
Li, Y., Zhang, Y., Wang, P., Chi, Y., Zhang, C., Ma, Y., Lv, C., Xie, S."Regression of A549 lung cancer tumors by anti-miR-150 vector ". Oncology Reports 27.1 (2012): 129-134.
Chicago
Li, Y., Zhang, Y., Wang, P., Chi, Y., Zhang, C., Ma, Y., Lv, C., Xie, S."Regression of A549 lung cancer tumors by anti-miR-150 vector ". Oncology Reports 27, no. 1 (2012): 129-134. https://doi.org/10.3892/or.2011.1466
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zhang Y, Wang P, Chi Y, Zhang C, Ma Y, Lv C and Xie S: Regression of A549 lung cancer tumors by anti-miR-150 vector . Oncol Rep 27: 129-134, 2012.
APA
Li, Y., Zhang, Y., Wang, P., Chi, Y., Zhang, C., Ma, Y. ... Xie, S. (2012). Regression of A549 lung cancer tumors by anti-miR-150 vector . Oncology Reports, 27, 129-134. https://doi.org/10.3892/or.2011.1466
MLA
Li, Y., Zhang, Y., Wang, P., Chi, Y., Zhang, C., Ma, Y., Lv, C., Xie, S."Regression of A549 lung cancer tumors by anti-miR-150 vector ". Oncology Reports 27.1 (2012): 129-134.
Chicago
Li, Y., Zhang, Y., Wang, P., Chi, Y., Zhang, C., Ma, Y., Lv, C., Xie, S."Regression of A549 lung cancer tumors by anti-miR-150 vector ". Oncology Reports 27, no. 1 (2012): 129-134. https://doi.org/10.3892/or.2011.1466
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