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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2012 Volume 27 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1

  • Authors:
    • Yu Jin
    • Hitoshi Murata
    • Masakiyo Sakaguchi
    • Ken Kataoka
    • Masami Watanabe
    • Yasutomo Nasu
    • Hiromi Kumon
    • Nam-Ho Huh

  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama 700-8558, Japan, Department of Cell Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
  • Pages: 695-699
    |
    Published online on: November 10, 2011
       https://doi.org/10.3892/or.2011.1543
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Abstract

REIC/Dkk-3 is a tumor suppressor gene that was first identified as a gene downregulated in association with immortalization of normal human fibroblasts. We have demonstrated that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) showed a tumor-specific killing effect on a wide range of cancers. However, some human cancers, bladder cancers in particular, are resistant to Ad-REIC. In this study, we investigated the combination effect of downregulation of BRPK/PINK1 (PINK1) and Ad-REIC on bladder cancer cells. Five bladder cancer cell lines among six cell lines examined were resistant to Ad-REIC. Among the cell lines, the resistance of two cell lines was probably due to low infection efficiency of the adenovirus. PINK1-specific siRNA remarkably downregulated Bcl-xL and TRAP1 proteins and upregulated BAX protein expression. Finally, downregulation of PINK1 partially sensitized the other three cell lines that were resistant to Ad-REIC. This sensitization was associated with increasing production of reactive oxygen species (ROS). These results indicate that PINK1 is one of the key molecules for the mitochondrial protection system and that PINK1 can be a new target molecule to sensitize bladder cancer cells that are resistant to Ad-REIC.

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Copy and paste a formatted citation
Spandidos Publications style
Jin Y, Murata H, Sakaguchi M, Kataoka K, Watanabe M, Nasu Y, Kumon H and Huh N: Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1. Oncol Rep 27: 695-699, 2012.
APA
Jin, Y., Murata, H., Sakaguchi, M., Kataoka, K., Watanabe, M., Nasu, Y. ... Huh, N. (2012). Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1. Oncology Reports, 27, 695-699. https://doi.org/10.3892/or.2011.1543
MLA
Jin, Y., Murata, H., Sakaguchi, M., Kataoka, K., Watanabe, M., Nasu, Y., Kumon, H., Huh, N."Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1". Oncology Reports 27.3 (2012): 695-699.
Chicago
Jin, Y., Murata, H., Sakaguchi, M., Kataoka, K., Watanabe, M., Nasu, Y., Kumon, H., Huh, N."Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1". Oncology Reports 27, no. 3 (2012): 695-699. https://doi.org/10.3892/or.2011.1543
Copy and paste a formatted citation
x
Spandidos Publications style
Jin Y, Murata H, Sakaguchi M, Kataoka K, Watanabe M, Nasu Y, Kumon H and Huh N: Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1. Oncol Rep 27: 695-699, 2012.
APA
Jin, Y., Murata, H., Sakaguchi, M., Kataoka, K., Watanabe, M., Nasu, Y. ... Huh, N. (2012). Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1. Oncology Reports, 27, 695-699. https://doi.org/10.3892/or.2011.1543
MLA
Jin, Y., Murata, H., Sakaguchi, M., Kataoka, K., Watanabe, M., Nasu, Y., Kumon, H., Huh, N."Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1". Oncology Reports 27.3 (2012): 695-699.
Chicago
Jin, Y., Murata, H., Sakaguchi, M., Kataoka, K., Watanabe, M., Nasu, Y., Kumon, H., Huh, N."Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1". Oncology Reports 27, no. 3 (2012): 695-699. https://doi.org/10.3892/or.2011.1543
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