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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2012 Volume 27 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin

  • Authors:
    • Qinqin Zuo
    • Wenjing Wu
    • Xu Li
    • Le Zhao
    • Wei Chen

  • View Affiliations / Copyright

    Affiliations: Center for Laboratory Medicine, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, P.R. China, Clinical laboratory, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, P.R. China
  • Pages: 819-824
    |
    Published online on: November 15, 2011
       https://doi.org/10.3892/or.2011.1553
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Abstract

Histone deacetylase 6 (HDAC6) promotes cell motility and contributes to the metastasis of cancers. The purpose of this study was to investigate the role of HDAC6 in human bladder cancer for the first time. The results showed that HDAC6 promotes the migration and invasion of bladder cancer cells by targeting the cytoskeletal protein cortactin. Furthermore, a colony formation assay as well as in vitro migration and invasion assays demonstrated that this migration and invasion was suppressed by the HDAC6-specific inhibitor tubacin. In addition, cortactin is the substrate of SIRT2, which also belongs to the family of histone deacetylases. We demonstrated that by using SIRT2-specific siRNA combined with tubacin treatment, the cell migratory and invasive abilities were dramatically suppressed. Taken together, we conclude that HDAC6 and SIRT2 work synergistically to promote cell migration and invasion in bladder cancer, and the HDAC6-specific inhibitor tubacin may be regarded as a novel therapeutic agent for bladder cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Zuo Q, Wu W, Li X, Zhao L and Chen W: HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. Oncol Rep 27: 819-824, 2012.
APA
Zuo, Q., Wu, W., Li, X., Zhao, L., & Chen, W. (2012). HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. Oncology Reports, 27, 819-824. https://doi.org/10.3892/or.2011.1553
MLA
Zuo, Q., Wu, W., Li, X., Zhao, L., Chen, W."HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin". Oncology Reports 27.3 (2012): 819-824.
Chicago
Zuo, Q., Wu, W., Li, X., Zhao, L., Chen, W."HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin". Oncology Reports 27, no. 3 (2012): 819-824. https://doi.org/10.3892/or.2011.1553
Copy and paste a formatted citation
x
Spandidos Publications style
Zuo Q, Wu W, Li X, Zhao L and Chen W: HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. Oncol Rep 27: 819-824, 2012.
APA
Zuo, Q., Wu, W., Li, X., Zhao, L., & Chen, W. (2012). HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. Oncology Reports, 27, 819-824. https://doi.org/10.3892/or.2011.1553
MLA
Zuo, Q., Wu, W., Li, X., Zhao, L., Chen, W."HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin". Oncology Reports 27.3 (2012): 819-824.
Chicago
Zuo, Q., Wu, W., Li, X., Zhao, L., Chen, W."HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin". Oncology Reports 27, no. 3 (2012): 819-824. https://doi.org/10.3892/or.2011.1553
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